The Clinical Value Of Alone And Combinative Measurements Of Serum SA, EMA And GPDA In The Diagnosis Of Gastric Cancer

Objective:We intend to analyse and detect the expression of serum SA, EMA and GPDA with non-atrophic gastritis, gastric precancerous lesions and gastric cancer in patients and analyse the relationships among them, and this paper also analyzes the relationship with the biology behavior of gastric carcinoma, in order to evaluate the values of alone and combinative measurements of serum SA, EMA and GPDA in the diagnosis of gastric cancer.Methods:We apply enzyme kinetic assay,continuous monitoring and ELISA methods to detect serum SA,EMA and GPDA in 30 cases of patients with gastric cancer patients ,25 cases of patients with gastric precancerous lesions and 35 cases of patients with non-atrophic gastritis with electronic gastroscope and pathological examination confirmed, compare the relevance of the groups,and then the sensitivity, specificity, diagnosis accuracy and positive likelihood ratio were calculated about alone and combinative measurements of the markers in the diagnosis of gastric cancer. and analyze the relationship between the expressions of them and clinical biology of gastric carcinoma .All dates were processed by SPSS 13.0 analysis software .Results:The serum concentrations of SA and GPDA in gastric carcinoma are remarkably higher than those in non-atrophic gastritis and gastric precancerous lesions (P< 0.05 ). A single detection of SA in the most sensitive (50.00%), GPDA the highest specificity (97.14%), one of the diagnostic accuracy GPDA the highest (90.99%), and the greatest diagnostic value (LR += 11.65). Joint detection SA, GPDA can improve the diagnostic sensitivity (53.33%), serum EMA is not a valuable marker in the diagnostic of gastric cancer(P>0.05). The concentrations of GPDA in non-atrophic gastritis group are age-related (P <0.05) and the concentrations of SA in the invasion stage is obviously higher than the localized stage (P<0.05), There are no obvious correlations between the levels of the other groups with the clinical biology behavior of gastric carcinoma(P>0.05). Conclusion:It has an important reference value for the diagnosis of gastric cancer to detect serum SA and GPDA. the Joint Detection SA and GPDA can improve the accuracy of the diagnosis of gastric cancer. EMA serum possibly has no diagnostic value for gastric cancer. The expressions of SA,GPDA in serum are related to the biology behaviors of gastric carcinoma, and to test the concentrations of SA,GPDA in serum is helpful in judging metastasis and recrudescence, and monitoring prognosis. serum GPDA levels in non-atrophic gastritis group increased with age.