Effects Of Cardiopulmonary Bypass On The Levels Of Plasma Neuropeptide Y During Peri-CPB Period Of Rheumatic Valvular Replacements

Objects:To detect the levels of neuropeptide Y(NPY) during peri-CPB period of valvular replacements and determine effcts of Cardiopulmonary Bypass on the levels of plasma neuropeptide Y during peri-CPB period of rheumatic valvular replacements.Methods:20 patients of rheumatic valvular disease going to be performed the operation of rheumatic valvular replacements were chosen in hospital.Blood samples were collected for blood routine examinations and the measurement of NPY by radioimmunoassay method as many as 4 times during peri-CPB period of these operations.The schedule of sample taking was as follows:before the operation,during CPB at 5 min,termination of CPB,and 24 h after the opertation.Results:(1)The levels of NPY during CPB at 5 min and at termination of CPB were significantly higher than the preoperative baselines(P=0.00),and they descended at 24 h after operation,but were still higher than the preoperative baselines(P=0.02).(2) The quantity of platelet during CPB and at termination of CPB were significantly less than the preoperative baselines(P=0.00),and they ascended at 24 h after operation,but were still less than the preoperative baselines(P=0.00) (3)The time of CPB was positive correlation with the level of NPY at termination of CPB(r=0.54,P=0.01).(3)The ascent of NPY was positive correlation with the descent of platelet at termination of CPB(r=0.48, P=0.03).Conclusions:(1)CPB causes the levels of plasma NPY during peri-CPB period of rheumatic valvular replacements ascended.(2)The changes of NPY during peri-CPB period of rheumatic valvular replacements is relating to the broken of platelet during CPB. (3)Reducing the time of CPB and protecting platelet can reduce the level of NPY and may reduce the injury of CPB and the opportunity of postoperative complications.