Effect Of Atorvastatin On Endothelial Function And Inflammation Factor In Patients With Acute Coronary Syndrome

Objectives:To investigate the effect of short term atorvastatin(40mg/d and 20mg/d) treatment on serum asymmetric dimethylarginine(ADMA) and high-sensitivity C reactive protein(hs-CRP) levels in patients with acute coronary syndrome(ACS).Methods:Forty patients ACS were randomly divided to two groups to receive atorvastatin 20mg/d(group 20mg/d) or 40mg/d(group 40mg/d) on the basis of standard treatment for one week.Serum ADMA and hs-CRP levels were assessed at baseline and 1 w after therapy.Results The two groups had similar serum lipids,ADMA and hs-CRP levels at baseline.After 1w,serum total cholesterol levels significantly decreased in both groups(P＜0.01).Serum triglyceride and low-density lipoprotein cholesterol levels significantly decreased in group 40mg/d(P＜0.01) but not in group 20mg/d.The changes in serum high-density lipoprotein cholesterol and lipoprotein(a) levels did not reach statistical significance in both groups.After 1w,serum hs-CRP levels significantly decreased in both groups(P＜0.01) without significant difference between two groups.Serum ADMA levels significantly decreased in both groups (P＜0.01).The percent change of serum ADMA level in group 20mg/d was significantly lower than that in group 40mg/d(28.3±6.6%:51.4±6.7%,P＜0.01).The change of ADMA level was not significantly related to those of lipids and hs-CRP levels,respectively.Conclusions Short term atorvastatin(40mg/d and 20mg/d) treatment significantly decreased serum ADMA and hs-CRP levels in ACS patients.Atorvastatin 40mg/d was more powerful in reduce ADMA level,which may confer better clinical benefit to ACS patients.