Small Cell Lung Cancer Complicating Syndrome Of Inappropriate Antidiuretic Hormone Secretion

Objective : To report a series of cases of small cell lung cancer(SCLC)with syndrome of inappropriate antidiuretic hormone secretion(SIADH) to investigate its diagnosis, treatment and clinical feature, Improve the diagnosis and treatment of the disease.Method: Retrospectively analyzed 7 patients with SCLC complicating SIADH treated in Shandong provincial hospital from June 2006 to February 2009.Results:Seven patients, three men and four women aging from 40 to 66 years being treated of lung cancer were finally diagnosed as SCLC with SIADH. Sodium level was 109-125mmol/L before treatment. After treatment including fluid restriction, chemotherapy and surgery, the sodium level returns to normal.Conclusion:SIADH was always complicated with SCLC. To diagnosis patients with lung tumor-associated SIADH, SCLC should be considered firstly. SIADH disappears after the excision of the tumor or chemotherapy.