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The Effects Of Serum Drug Concentration Of Clinical Research With Yishen Jianpi After Renal Transplantation On Tacrolimus (FK506)

Posted on:2010-01-20Degree:MasterType:Thesis
Country:ChinaCandidate:J WangFull Text:PDF
GTID:2144360278975911Subject:Integrative Medicine
Abstract/Summary:PDF Full Text Request
Purpos: Use Jianpi Yishen method, select Shenling Baishu San and Liuwei Dihuang Decoction treat, observe the rate of the patients' enhancement of Tacrolimus (FK506) blood concentration after the renal transplantation. Clinical evaluation of the degree of symptom improvement, analyze and discuss the related applications and mechanism of Chinese medicine and Chinese herbal medicine after renal transplantation, to find a treatment of traditional Chinese and western medicine for patients after renal transplantation.Method: In accordance with the standards included in this study, collect cases and exclude criterion, finally retained 8 cases, taking Shenling Baishu San Liuwei Dihuang Decoction, monitor the concentrations of drug FK506, clinical symptom score, hemoglobin, white blood cells, platelets, neutrophils / lymphocytes, red blood cell count, white blood cell count, urine protein and occult blood, alanine, aspartate, serum total bilirubin, direct bilirubin, indirect bilirubin, blood urea nitrogen , creatinine, uric acid, and other targets respectively when pretreatment, after one week's treatment and after two weeks' treatment. All data should be typed into the computer, set up excel database, and then use the SPSS17.0 statistical software to analyze the data.Result:①The basic information of cases and data: 5 cases of male patients (62.5%), 3 cases of female patients (37.5%); maximum age 45 years old and the youngest 21-year-old age, 3 people less than or equal to 30-year-old (37.5%), 3 people who are 31 ~ 40-year-old (37.5%), 2 people who are 41 ~ 50-year-old ( 25%);②The changes of the concentrations of drug FK506: the concentration of the drug FK506 is 4.98±1.45ng/ml after one week's treatment, the concentration of the drug FK506 is 7.39±3.36ng/ml after two weeks' treatment, there is a significant clinical effect compared with pre-treatment 3.84±0.78 ng / ml;③Changes of clinical symptoms: Clinical symptoms score decreased to 21.88±3.56, 12.50±4.72 respectively from 51.25±8.97 of pretreatment, there is significant improvement in clinical symptoms; ④Analysis of the relevant targets: Compare two weeks' treatment of uric acid target with pretreatment, P<0.05, there is significant difference, the remaining blood, urine, liver and kidney function of the observation of the target group compared with each other, all P>0.05, don't have significance.Conclusion: After the treatment of Jianpi Yishen, the concentrations of drug FK506 has markedly improved, clinical symptoms have significant improvement, inhibitor to reduce side effects, promote the restoration of renal function, thus adjust the dosage of tacrolimus, light the financial burden of patients. Chinese medicine and Chinese herbal medicine have a more extensive prospect after the renal transplant recipients.
Keywords/Search Tags:Jianpi Yishen Method, After the Renal Transplantation, Tacrolimus concentration, Clinical Symptoms
PDF Full Text Request
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