Clinical Efficacy Of Wushen Erlian Granule On Ventricular Premature Beat Of Qi-yin Deficiency Syndrome

Objective: To observe the clinical efficacy of Wushen Erlian granule on ventricular premature beat (VPB),in TCM as palpitation of Qi-yin deficiency syndrome, and cardiovascular autonomic nervous function in patients.Methods: The randomized , double-blind , parallel contrast method was adopted, patients were randomly assigned by 1 : 1 ratio into two groups. Forty patients in Wushen Erlian granule treated group and forty patients in the control group (treated with Metoprolol) ,and the therapeutic course for both groups was 4 weeks.Results: (1) The clinical efficacy on VPB and in improving TCM syndromes was better in Wushen Erlian granule group than that in the control group (P < 0.01) (2) After treatment, the heart rate variability (HRV),HRT and QT dispersion in the two groups were improved in a certain degree. The changes of SDNN,SDANN,SDNN Index and PNN50 in the two groups were significantly different (P < 0.05 , P < 0.01), the efficacy in the treated group was superior to that in the control group. The changes of turbulence onset (TO),turbulence slope (TS) in two groups were significantly different ( P < 0.01), the efficacy in the treated group was superior to that in control group.Conclusion : Wushen Erlian granule has definite effect on VPB and TCM Syndromes , it can obviously meliorate the activity of cardiovascular autonomic nervous system in the patients.