Study Of PSA Relevant Parameters In Prostate Cancer By Three-dimensional Transrectal Ultrasonography

Objective:To investigate the usefulness of prostate specific antigen(PSA) relevant parameters in the diagnosis of prostatic carcinoma (PCa) with measuring the prostatic volume by three-dimentional ultrasonography.Methods:78 patients who had been carried out transrectal ultrasound guided prostate biopsy were involved in this study. Among them, 27 patients were proved to be suffering from PCa, and other 51 patients were identified as benign prostate hypertrophy (BPH). The prostatic volume and its transition zone volume were measured by three-dimentional ultrasonography. Then the PSA relative parameters (f/tPSA, PSAD, PSAT, (F/T)/PSAD and (T/F)/PV) were calculated.Results:The difference of f/tPSA, PSAD, PSAT, (F/T)/PSAD and (T/F)/PV between PCa and BPH has arrived statistical significance ( P < 0.05). In ROC curves, area under the curve of them were 0.635, 0.723, 0.736, 0.760, 0.800, 0.784 respectively. At the same higher sensitivity(88.9%) , the parameter whose specificity was from low to high was f/tPSA, PSAD, PSAT, (T/F)/PV and (F/T)/PSAD.Conclusions:When the serum PSA level between 4μg/L and 20μg/L, f/tPSA, PSAD, PSAT, (F/T)/PSAD and (T/F)/PV are of significant value to differentiate PCa from BPH patients. A cutoff is recommended according the sensitivity and specificity balance: f/tPSA<0.15, PSAD>0.20μg/(L.cm3), PSAT>0.33μg/(L.cm3), (F/T)/PSAD<0.8, (T/F)/PV>0.2.