Exploration Of The Value Of CT For Early Diagnosis Of Pulmonary And Extrapulmonary Acute Respiratory Distress Syndrome In A Rabbit Model

Objective:Acute respiratory distress syndrome(ARDS), mostly triggered by underlying multi-causes such as sepsis,severe trauma,shock and others, is the manifestations of systemic inflammatory response syndrome(SIRS) in the lungs, and the terminal phase of serious acute lung injure(ALI). At present, although the diagnosis and treatment of ARDS has made great progress, in most patients with ARDS, not until the disease developped to the middle or late stage can we make clinical diagnosis because of lack of early and sensitive marker for diagnosis. It is hard to cure and resulting in the mortality remains high. Therefor, to study new methods for the early diagnosis of ARDS is one of the most chanllenging entity we are facing now. In our research, we investigate the value of CT for early diagnosis by measuring the changes of different lung compartments of rabbits with ARDS caused by pulmonary and extrapulmonary disease, and try to find new methods for the early diagnosis of ARDS, which will facilitate early identification and intervention in the disease course and improve the prognosis of patients with ARDS.Methods:Thirty white rabbits were randomly divided into ARDSp group (ARDS caused by pulmonary disease),ARDSexp group (ARDS caused by extrapulmonary disease) and normal control group. In ARDSp group, normal saline was administered intratracheally to induce lung injury, and in ARDSexp group, oleic acid was given intravenously to induce lung injury, while the normal control group was injected with the same amount of normal saline, with 10 in each group. Arterial blood gas analysis was measured every 15 min. All rabbits underwent chest X-ray and lung spiral CT scans at base time point (T₀),300 mm Hg< oxygenation index(OI)≤400 mm Hg (T₁),200 mm Hg