Measurement And Significance Of Peripheral Blood Matrix Metalloproteinase-2, Interleukin-18 And Fibrinogen In Patients With Acute Coronary Syndrome

ObjectiveTo investigate the changes of concentrations for matrix metalloproteinase-2, interleukin-18 and fibrinogen in patients with acute coronary syndrome(ACS).Methods56 patients with ACS from inpatients in Department Cardiology between August 2008 and September 2009, including 32 patients with unstable angina pectoris (UAP) and 24 patients with acute myocardial infarction (AMI),were enrolled in the ACS group,36 patients which conditions were stable in the SAP group.,40 healthy persons in the control group.The levels of MMP-2 and IL-18 were measured by ELISA at the 1 day, the 3 day and the 10 day after admission to hospital, the levels of fibrinogen were measured by Clauss at the 1 day after admission to hospital. All patients wth ACS were experienced coronary arteriography when the conditions were stable.Result1.The levels of MMP-2 and IL-18 were higher in the UA group than in the control group at the 1 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the UA group than in the SAP group at the 1 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in the control group at the 1 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in SAP group at the 1 day after admission to hospital(P<0.05). There were no significant differences for the levels of fibrinogen among UA group, SAP group and control group (P>0.05) There were no significant differences for the levels of fibrinogen among AMI group, SAP group and control group (P>0.05)2. The levels of MMP-2 and IL-18 were higher in the UA group than in the control group at the 3 day after admission to hospital (P<0.05) The levels of MMP-2 and IL-18 were higher in the UA group than in SAP group at the 3 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in the control group at the 3 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in SAP group at the 3 day after admission to hospital (P<0.05)3. The levels of MMP-2 and IL-18 were higher in the UA group than in the control group at the 10 day after admission to hospital (P<0.05) The levels of MMP-2 and IL-18 were higher in the UA group than in SAP group at the 10 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in the control group at the 10 day after admission to hospital (P<0.05). The levels of MMP-2 and IL-18 were higher in the AMI group than in the SAP group at the 10 day after admission to hospital (P<0.05)4. There are no correlations between MMP-2 and IL-18 in the UA group and AMI group.5. In patients with ACS, MMP-2 elevation at the 1 day after onset was followed by a gradual decrease up to day 10 whereas IL-18 elevation with a peak on day 3. ConclusionMMP-2 and IL-18 play an important role in the rupture of unstable atherosclerotic plaque, they can be used to early prediction of ACS and risk stratification for ACS. Inflammation is the main mechanism in the rupture of vulnerable plaque.