Study Of Serum Apelin Level And Mechanism In The Patients Of Metabolic Syndrome

Objective To investigate the changes of the serum apelin level and its mechanism in patients with metabolic syndrome.Methods Sixty-nine patients with metabolic syndrome and Sixty-three subjects with normal glucose regulation (NGR) were selected and the former was divided into metabolic syndrome with T2DM(MS I group) and metabolic syndrome with impaired glucose regulation(MS II group) subgroups according to the levels of blood glucose, and the body mass index(BMI)≥25kg/m2;the latter was divided into overweight/obesity and normal control(NC) subgroups according to body mass index(BMI)≥25kg/m2 or <25kg?m2 and the normal control(NC) subgroups'body mass index(BMI)≥18.5kg?m2. Meanwhile, the height, weight, waist circumference, blood pressure, fasting insulin, fasting plasma glucose (FPG), HbA1C and lipid profile level were also measured, BMI and insulin sensitivity was assessed by HOMA-IR. The level of fasting serum apelin was measured by ELISA .Results①Compared to normal control group, the fasting serum apelin concentration was increased in both MS and overweight/obesity groups(P<0.01). The fasting serum apelin level in MS combined with type 2 diabetes mellitus subgroup was significantly higher than that of impaired glucose regulation MS subgroup(P<0.05) and overweight/obesity group(P<0.01). The fasting serum apelin level in impaired glucose regulation MS subgroup was significantly higher than that of overweight/obesity group(P<0.05). The level of fasting serum apelin,FINS,ln(HOMA-IR),FPG,2hPG,HbA1C,SBP,TC,LDL-C in MS was significantly higher than that of the normal glucose regulation(all P<0.05).②Correlation analysis showed that the serum apelin was positively correlated to Weight,BMI,Waist,SBP,FPG,2hPG,HbA1C,TC,LDL-C,FINS,ln(HOMA-IR) (r=0.187, r= 0.494, r=0.425, r=0.585, r=0.496, r=0.546, r=0.457, r=0.351, r=0.235, r=0.509, r=0.600, all P<0.05).③Partial correlation analysis showed that the serum apelin was also positively correlated to ln(HOMA-IR),FINS,TC(r2=0.211, r2=0.178, r2=0.223, all P<0.05).④In a multiple step-wise regression analysis, ln(HOMA-IR), BMI and TC were independent factors related to apelin (r2=0.544, r2=0.494, r2=0.293, all P<0.05).Conclusions①It maybe the increased insulin resistance which caused the level of serum apelin increased in the patients with MS group.②The increased of serum apelin level is closely related to overweight/obesity, diabetes/impaired glucose regulation, hypertension, dyslipidemia and other metabolic abnormalities of metabolic syndrome.