T2DM With Lipid Metabolism And Insulin Resistance And Insulin Secretion Correlation Analysis

Objectives To investigate the relationship between type 2 diabetic patients with lipid metabolism and insulin resistance, islet ? cell function, providing a theoretical basis for type 2 diabetes prevention and treatment of lipid metabolism disorders.Methods Selected in May 2014- May 2015 in the Affiliated Hospital of North China University of Technology Department of Endocrinology, type 2 diabetic patients hospitalized for the study of 284 cases, 163 cases were male, female 121 cases; age 25 to 80 years, average 52.48 ± 10.31 years, in line with the diagnostic criteria for diabetes 1999 World Health Organization(WHO) to develop; in accordance with the 2007 "China adult dyslipidemia prevent Guide" subjects were divided into two groups, normal blood lipid group(160 cases) and dyslipidemia group( 124 cases). Selected objects are measured height, weight, waist circumference(WC), and calculate the patient's body weight index(BMI) and waist / height ratio(WHt R). Fasting plasma glucose(FPG), 2-hour postprandial glucose(2-h PG), glycated hemoglobin(Hb A1c), fasting C-peptide(FC), fasting insulin(FINS), triglyceride(TC), cholesterol(TG), high density lipoprotein(HDL-C), low density lipoprotein(LDL-C). Homeostasis model assessment of insulin resistance and islet ? cell secretory function was evaluated.Results 1 dyslipidemia group BMI higher than normal blood lipid group, the difference was statistically significant(P<0.05). 2 dyslipidemia group glycated hemoglobin higher than normal blood lipid group, the difference was statistically significant(P<0.05). 3 dyslipidemia patients fasting insulin, fasting C-peptide is higher than normal blood lipid group, the difference was statistically significant(P<0.05); dyslipidemia patients HOMAIR, HOMA-? higher than normal blood lipid group, the difference was statistically significant(P<0.05). 4 The chi-square test results showed that patients with dyslipidemia group HOMA-IR?3.52 proportion of larger than normal blood lipid group, the difference was statistically significant(P<0.05); dyslipidemia group HOMA-?<40 patients occupied lipid ratio is less than the normal blood lipid group, the difference was not statistically significant(P>0.05). 5 To type 2 diabetes patients with disorder of lipid metabolism as the dependent variable and gender, age, course of disease, WHt R, BMI, FPG, 2h PG, Hb A1 c, fasting insulin(fins) and fasting C peptide, HOMA-IR and HOMA-? as independent variables for multivariate non conditional logistic regression analysis, the indicators between correction. The results showed that high levels of HOMA-IR as an independent risk factor for type 2 diabetic patients with disorder of lipid metabolism(P< 0.05).Conclusions In patients with type 2 diabetes, the disorder of lipid metabolism is associated with insulin resistance, high insulin resistance index and increased risk of lipid metabolism disorder.