Influence Of Ginsenoside Re On Inflammation And PGI₂/TXA₂ System Of Myocardium Ischemia-Reperfusion Injury

The normal metabolism and function of the tissues and organs are dependent on good blood circulation,if the blood supply of hearts decreases ,myocardium will be injured because of absolute or relative ischemia.By the experiments, we know that blood stream resuming after brief ischemia may caused myocardium injuried worse because of myocardial ischemia reperfusion injury (MIRI).Because the cardiovascular disease incidence rate increase,it is necessary to search a effective and safe traditional Chinese medicine to prevent MIRI. In this study ,We have evaluated the influence of Ginsenoside Re on the parameter of blood stream dynamics of Myocardium Ischemia-Reperfusion Injury,inflammation,PGI2/ TXA2 System,and MDA,SOD of serum.Method:The MIRI models of Wistar rats in vivo were induced by ischemia left anterior descending coronary artery(LAD) for 30min and reperfused for 12 hours. We detected the effect of Ginsenoside Re on blood plasma of blood stream dynamics ;the inflammatory cytokines TNF-αand IL-1βof serum with RIA; and detected the SOD and MDA of serum;Observed the PGI2/ TXA2 System by detected the content of 6-keto-PGF1αand TXB2.Result: 1. Compare with the MIRI group, SBP,DBP,MAP,LVSP,±dp/dtmax and HR of much dose group all increased obviously.In little dose group, SBP,DBP,LVSP,MAP,- dp/dtmax and HR increased,others have no significant changes; 2.Ginsenoside Re can decrease the inflammatory cytokines of TNF-αand IL1-βsignificantly; 3.Compare with the MIRI group,the group with Ginsenoside Re can decrease the content of TXB2 and the ratio of TXB2/6-keto-PGF1α,raise the content of 6-keto-PGF1αat the same time;4. Ginsenoside Re can decrease the content of MDA,and raise the SOD activeness prominent.Conclusions: 1. Ginsenoside Re can improve the parameter of blood stream dynamics of Myocardium Ischemia-Reperfusion Injury; 2. Ginsenoside Re can decrease inflammatory factors of TNF-αand IL1-β, reduce the injury of myocardial tissue; 3.Adjusts the PGI2 /TXA2 balance; 4. Reduce the ROS,and reduces the injured myocardium of ischemia-reperfusion.