Clinical Analysis Of Combined Intervention Treatment For Primary Liver Cancer

The specialized characters of primary liver carcinoma(HCC), such as its occult occurrence and rapid growth, makes it as one of the most formidable disease in malignant tumors all over the world. Surgical resection is the preferred treatment for HCC, but it is only suitable for treatment of liver cirrhosis or merger of small HCC patients with mild liver cirrhosis. And only 10~30 % patients can accept radical excision surgery after HCC was diagnosed. It is difficult to thoroughly amputate HCC because most of the patients belong to middle-late, most associated with cirrhosis of the liver, such as hepatitis, radical excision. Interventional therapy is currently accepted as a main and unresectable method for HCC treatment. Various of Interventional therapy can suppress tumor growth, improve patient surial, enhance curative effect, but they have their advantages and disadvantages. Combination therapy can compensate their mutually deficiencies and improve overall effect.Objective: To explore more effective intervention model, improve the treatment of liver and provide guidance for HCC treatment by retrospectively analyzing transcatheter arterial chemoembolization(TACE), transcatheter arterial chemoembolization combined percutaneous ethanol injection(TACE+PEI) and transcatheter arterial chemoembolization combined 125I(TACE+125I).Methods: The patients including deaths during the follow-up who have PLC and followed up for tow or more than two years were retrospectively analyzed and divided into 3 groups. A group is the control group .A group including 45 patients were treated by TACE. B and C group were expermental groups. There were 28 patients in B group who were treated by TACE+PEI. C group inclouded 16 patients who were treated by TACE+125I. The degree of tumor's decrease was observered by CT, MRI and ultrasound during 1,3,6 months according WHO RECIST and"Standardized Interventional Treatment Of Hepatocellular Carcinoma"Survival rate and median survival time of one and two years among 3 groups were compared. The effect of interventional therapy to hepatic function was evalued according the Child-Pugh. Then the effect of treatment was assessed by TNM(2002).Results: Tumor minification and tumor control situation of B and C group were higher A group. This difference among three group was statistically significant(p<0.005).The difference of survival rate between 1 year and 2 years was not statistically significant. In hepatic function after operation , the improvement rate of B and C was higher than A ,the deterioration rate of B and C was lower than A.Conclusion: this study adopted in interventional therapy method has good curative effect, but the effect of combination interventional therapy is more effective than pure interventional treatment.