Clinical Observation Of The Short Term Effect Of Different Neoadjuvant Chemotherapy Regimen In Breast Cancer

Objective:To compare and analysis the effect and side effect of two neoadjuvant chemotherapy regimens (FEC and TE).Methods:The data of 43 female patients with Stageâ…¡a,â…¡b andâ…¢a breast cancer was retrospectively analyzed. These patients with average age 51.5 were enrolled into the department of surgical oncology, the second affiliated hospital Zhejiang university college of medicine from February 2009 to November 2009. All patients with non-metastasis tumors were received neoadjuvant chemotherapy with two to four cycles of FEC or TE regimen before operation. Karnofsky score is more than 80. All tumors were identified by core needle biopsy before neoadjuvant chemotherapy. Response rate was evaluated after neoadjuvant chemotherapy and the pCR, cCR, RR were analyzed with the help of SPSS FOR WINDOWS 16.0.Results:Among all the 43 patients with operable breast cancer,25 patients with breast cancer received FEC regimen before operation, the rate of cCR, RR and pCR was 20.0%(5/25),72.0%(18/25) and 8.0%(2/25) respectively,18 patients received TE regimen, the rate of cCR, RR and pCR was 16.7%(3/18),77.8%(11/25) and 0 (0/18) respectively. In the differences of the clinical response rate between FEC and TE regimen, there were no significant differences (p>0.05). The side effect between them is similar, which mainly conclude nausea and vomiting, leukopenia and alopecia.Conclusion:Two neoadjuvant chemotherapy regimens (FEC and TE) both are effective and the side effect is tolerable.