| Objective:To analyze retrospectively on the out-patient cases of 311 patients with skin tumorMethod:The patients with clinical or pathological diagnosis as skin tumors from 2008 to 2009 were studied in the Department of Dermatology of the Second Affiliated Hospital of Medical College of Zhejiang University. A total data of 333 cases of patients(including 311 cases which were pathologically confirmed as skin tumors,132 cases in 2008,179 cases in 2009) were classified and analyzed. Application of SPSS 15.0 package was used for data processing and the Chi-Square Test was used for the comparison of the rate, p<0.05 was considered to be statistically significant.Results:①There were 163 males(52.41%),148 females(47.59%). The gender ratio of male to female was about 1.10:1 in this group;②There were about 226 cases(72.67%) of benign tumors, with 115 males and 111 females,21 cases(6.75%) of pre-malignant or benign tumors at the junction of malignancy, with 13 males and 8 females, and 64 cases(20.58%) of malignant tumors, with 35 males and 29 females. There was no significantly different in the rate of the benign tumor between male and female by the means of Chi-Square Test(x2=0.379, p>0.05), while there was also no significantly different in the rate of the malignant tumor between male and female by the means of Chi-Square Test(x2=0.167, p>0.05);③50 different species of skin tumors were found in this group, which were categorized according to the origins of the tissue organization: 149 cases(47.91%) of epidermal tumors,26 cases(8.36%) of epiderm-adnexal tumors, 63 cases(20.26%) of melanocytic tumors,5 cases(1.61%) of nerval tumors,11 cases(3.54%) of vascular tumors and adipic tumors,34 cases(10.93%) of fibra and connective tissue tumors,21 cases(6.75%) of tissular tumors and lymphatic tumors,2 cases(0.64%) of metastatic carcinoma;④The tumors with largest sample number(more than 20 cases) of these species which were pathologically diagnosed in this group were as follows:seborrheic keratosis(80 cases), nevus(60 cases), basal cell carcinoma(25 cases), dermatofibroma(25 cases); There were 38 cases and 42 cases of seborrheic keratosis in 2008 and 2009, while 23 cases and 37 cases of nevus, These two diseases account for two-year rate of change in the total number of tumors was not statistically different(seborrheic keratosis x2=0.379, p>0.05; nevus x2=0.514, p>0.05).⑤Misdiagnosis rate were as follows:30%in seborrheic keratosis,10%in nevus,8%in dermatofibroma,12%in basal cell carcinoma. The consistency rate of clinical diagnosis with pathological diagnosis were as follows:60.22%in seborrheic keratosis,66.67%in nevus,78.57%in basal cell carcinoma,74.19%in dermatofibroma. Sixteen cases of seborrheic keratosis were misdiagnosed as nevus(66.67%from all misdiagnosed cases in seborrheic keratosis). There was significantly different in the misdiagnosis rate from these four kinds of skin tumors by the means of the Chi-Square Test(x2=12.416, p<0.01), whereas there was no significantly different in the consistency rate of clinical diagnosis with pathological diagnosis(x2=4.307, p>0.05).⑥In this group, the average age of the patients which were diagnosed as skin tumors was about 50.25±21.67 years old, with 50.20±23.58 years old in male and 50.30±19.44 years old in female. The youngest was 3 months years old and the oldest was 92-year-old. In the age groups(0-20 yrs), the rate of malignant tumor, pre-malignant or benign tumor at the junction of malignancy and benign tumor was 2.8%,2.8%and 94.4%respectively; In the age group(21-40 yrs) was 8.1%,4.8%and 87.1%respectively; In the age group(41-60 yrs) was 16.8%,4.7%and 78.5%respectively; Old age group(61 yrs or older) was 33.7%,11.3%and 50.9% respectively. There was significantly different in the composition of malignant tumor, pre-malignant or benign tumor at the junction of malignancy and benign tumor from different age groups by the means of the Chi-Square Test(x2=42.809, p<0.01).⑦The rate of skin tumor in different parts of the body were as follows:36.66%(114 cases) on craniofacial and neck,27.33%(85 cases) on trunk,21.54%(67 cases) on limbs, 7.40%(23 cases) on hand and foot, and7.07%(22 cases) on perineum. The rate of malignant skin tumor in different parts of the body were as follows:23.68%(27 case) on craniofacial and necks,17.65%(15 cases) on trunk,17.91%(12 cases) on limbs,8.69%(2 cases) on hand and foot,33.36%(8 cases) on perineum. There was significantly different in the composition of malignant tumor, pre-malignant or benign tumor at the junction of malignancy and benign tumor from different parts of the body by the means of the Chi-Square Test(x2=17.798, p<0.05).Conclutions:①There is no statistically significant in the rate of the benign or malignant tumor between male and female.②There is statistically significant in the composition of malignant tumor, pre-malignant or benign tumor at the junction of malignancy and benign tumor from different age groups. The occurrence rate of malignant tumor is increasing with age.③There is statistically significant in the composition of malignant tumor, pre-malignant or benign tumor at the junction of malignancy and benign tumor from different parts of the body. The occurrence rate of malignant tumor in perineum, head and face are the highest.④Seborrheic keratosis, nevus, basal cell carcinoma and dermatofibroma are the most common skin tumors, but there is statistically significant in misdiagnosis rate from these four kinds of skin tumors. The highest rate of misdiagnosis exists in seborrheic keratosis.⑤The consistency rate of clinical diagnosis with pathological diagnosis from these four skin tumors was 60%-80%, but there is no statistically significant.⑥Epidermal tumors and melanocytic tumors accounte for the highest proportion of the total, with representatives disease seborrheic keratosis and nevus are the most common tumors. According to the chain in 2008 and 2009, These two diseases account for two-year rate of change in the total number of tumors is not statistically different. Clinical diagnosis between two diseases are used to be confused, attention should be paid when diagnosing such diseases. |
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