Alterations Of RCBF In Healthy Adults During Urine Withhold By ^99mTc-ECD SPECT Brain Imaging And Analyzed By SPM

ObjectiveIncontinence of urine is related with the pathological process of many brain diseases.The aim of this study was to identify cerebral activation areas during withholding urine in healthy subjects with cerebral perfusion agent[technetium-99m labelled ethylcysteinate dimmer (99mTc-ECD)].MethodsSixteen healthy volunteers(mean age 46 years old) were recruited. All had two brain perfusion SPECT scans:resting state with empty bladder and urine withholding state with full bladder. The images were analyzed by Statistical Parametric Mapping (SPM) and displayed at a significance threshold of P<0.05 with correction for multiple comparisons.ResultsAt the urine withholding state, there's a significant increase cerebral perfusion in the right parietal lobe, the bilateral superior frontal guri, the right inferior frontal gyri, the right superior temporal gyti and the left claustrum.ConclusionsThe control of urinary continence in healthy men was associated with the right parietal lobe, the bilateral superior frontal guri, the right inferior frontal gyri. Moreover, the combination of brain perfusion SPECT and SPM was a convenience, shortout method to align the functional areas of the brain.