Clinical Research On The Treatment Of Acute Cerebral Ischemic Stroke With NAO-QING Nasal Spray Microemulsion

Cerebral Ischemic Stroke also named as Cerebral Infarction, is a disease caused by encephalic blood supply barrier. Because of the blood supply barrier, brain cells occur unreversible damage till putrescence. The disease takes on high disease incidence and high fatality ratio and high mutilation ratio. There are two problems restrict the curative effect. The one is lacking of effective medicines. The anther is the medicines can not drill through blood-brain barrier. now, cerebral ischemic stroke becomes a puzzle of medicine domain in the world.Chinese have treated the disease with herb for more than 2000 years, and aquire some effect. We use the modern techniques of pharmaceutics, distill the main component of sime herbs, produce a new drug. We call it NAO-QING Nasal Spray Microemulsion.It is used to cure Acute Cerebral Ischemic Stroke by intranasal administration. And we except that we can receive better clinical effect.Objectives:To observe the effect of the treatment on Acute Cerebral Ischemic Stroke by NAO-QING Nasal Spray Microemulsion.Methods:All the 86 qualified patients were grouped randomly into 2 groups:42 in treatment group,44 in control group. The treatment group are treated by NAO-QING Nasal Spray Microemulsion (two spurt one time, three times one day). The treatment group are treated by Nimodipine Tablet(20mg one time, three times one day). Two groups are offerd basal treatment (blood pressure controlled, blood sugar controlled, dosing aspirin 100mg one day, controlling cerebral edema, treating infection, etc). The periods of treatment is 14 days.Results:1.The effective rate of treatment group was 95.24%, markedly effective rate was 78.57%, compared with control group (P<0.05). 2. The score of NIHSS and Living Ability in two groups were improved remarkably after treating 7days and 14 days (P<0.01). The score of teeatment group was improved more remarkably compared control group after treatment(P<0.01).It showed that both NAO-QING Nasal Spray Microemulsion and Nimodipine Tablet could improve the clinical symptoms, and the effect of NAO-QING Nasal Spray Microemulsion was better than Nimodipine Tablet.3. The score of Chinese medicine was improved remarkably in treatment group after treating 7 days and 14 days(P<0.01). But not improved in control group(P>0.05). Threr is remarkable difference between two groups after treating 7days and 14 days(P<0.01).It showed that NAO-QING Nasal Spray Microemulsion could improve the symptoms of Chinese medicine, but Nimodipine Tablet could not.4. All the indices of hemorheology were improved remarkably after treating 14 days in treatment group. Only two indices of hemorheology were improved after treating 14 days in control group. It showed that NAO-QING Nasal Spray Microemulsion could improve the hemorheology.5. The damaged area in encephalon CT was altered after treatment in both groups (P<0.01), but no remarkable difference between tow groups (P>0.05). The value of CT was altered remarkably after treatment in both groups ((P<0.01)). But treatment group altered less remarkably than control group.Conclusions:The clinical effect of NAO-QING Nasal Spray Microemulsion is better than Nimodipine Tablet. NAO-QING Nasal Spray Microemulsion might be effected by protecting encephalon cells which lack of blood and oxygen.