Expression And Significance Of AKT/mTOR Signal Pathway In Renal Clear Cell Carcinoma

Objective This study was to explore the expression of p-AKT and p-mTOR factors in clear cell carcinoma of kidney and to provide evidence for mTOR and AKT inhibitors used in renal clear cell carcinoma therapy.Methods The expression of p-AKT and p-mTOR in clear cell carcinoma of kidney and normal kidney tissue were measured by immunohistochemical method.Results The level of p-AKT p-mTOR and expression in renal clear cell carcinoma were significantly higher than in normal kindney tissues(p<0.01). The expression of p-AKT significantly associated with tumor clinical stage and the higher the clinical stage, the higher the rate of positive expression of p-AKT (P= 0.029<0.05). The expression of p-mTOR protein was relative with tumor clinical stage (P= 0.043 <0.05). The expressions of p-AKT and p-mTOR had close correlation with pathological grading (p-AKT:P-0.040<0.05; p-mTOR:P=0.014<0.05).The expression of p-AKT in renal clear cell carcinoma was positively correlated with p-mTOR (r= 0.953, P-0.000).Conclusion AKT/mTOR signaling pathway was over-activated in renal clear cell carcinoma. They may play an important role in occurrence and development of renal cell carcinoma. In theory, the mTOR and AKT inhibitors can be used to treat the renal cell carcinoma.