| Objective:To investigate effects and its biochemical mechanism of Astragalus Polysaccharides on learning and memory in mice.Methods:Forty mice were randomly divided into four groups, control group, Astragalus Polysaccharides low dose group(200mg/kg),middle dose group(400mg/kg) and large dose group(800mg/kg). It is ten in every group. The control group was administrated by physiological saline. The ascend platform latent period, all path, crossing platform number of times and platform quadrant residence time were measured, after intragastric administration three weeks. Then, the blood were obtained by extirpating eyeball in mice. superoxide dismutase activity and malondialdehyde content were determined by centrifuging the blood.Results:1. Effects of astragalus polysaccharides on common condition and weight in mice:After intragastric administration three weeks with Astragalus Polysaccharides in mice, the common contion were good. Moreover, all Astragalus Polysaccharides groups's mice weight hadn't significantly changed compaired with control group (P>0.05).2. Effects of astragalus polysaccharides on learning and memory:①Astragalus Polysaccharides with middle dose and large dose can shorten ascend platform latent period and all path compaired with control group in mice (P＜0.05), but not in low dose group(P>0.05).②Astragalus Polysaccharides with middle dose and large dose can increase crossing platform number of times and platform quadrant residence time compaired with control group in mice (P＜0.05), but not in low dose group(P>0.05).3. Effects of astragalus polysaccharides on SOD and MDA:Astragalus Polysaccharides with middle dose and large dose can increase SOD and degrade MDA compaired with control group (P＜0.05), but not in low dose group(P>0.05).Conclusion:Astragalus Polysaccharides can enhance the ability of learning and memory in mice. Its mechanism of action maybe concerned with enhancing anti-free radical in blood serum.
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