Studies On The Implication Of Serum Uric Acid In Essential Hypertension With Early Renal Damage

Objective:To observe the changes of serum uric acid in different groups of patients with essential hypertension and investigate the relationship between uric acid and early hepertensive renal damages.Materials and Methods:80 cases of essential hypertension with normal glomerular filtration rate (GFR) were selected during January and December in 2009. All patients were divided into 3 groups according to the degree of essential hypertension:Group A,25 cases with 1st degree hypertension; Group B,26 cases with 2nd degree hypertension; Group C,29 cases with 3rd degree hyertension. The following conditions were excluded from this study:patients suffering from gout; patients who had taken uric acid-lowering drugs and diuretics in 5 days before blood test; people who had taken too much purine or liquor for long time; patients with diabetes mellitus, hyperlipidemia and obesity; secondary hypertension patients. Height and weight were measured to calculate body mass index. All selected people were asked to take vegetarian diet and restrict drugs which can affect uric acid metabolism for 5 days before blood sampling.5ml fasting venous blood was collected to detect serum uric acid, total cholesterol, triglyceride, and blood glucose by LY-20 automatic biochemical analyzer (USA).24 hour urine were collected to measure albunim turbidity by BeckmanArray360 automatic scattering Determination(USA). Data were analyzed using SPSS 12.0 software package. Variance analysis and t test were used in the comparison among different groups.χ2 test was used for catagorized data. P<0.05 was regarded as the statistical significance.Results:.1.There was no significant difference between the hyperten-sion group and the control group in sex,age,IBM,TC,TG,FBG et al (P>0.05). 2.The serum uric acid level in the hypertension group was significantly higher than that in the control group(P<0.01),and the morbidity of HUA in the hypertension group was also significantly higher than that in the control group(P<0.01).3.The SUA level in the 2 degree hypertension group was significantly higher than that in the 1 degree hypertension group(P<0.01), the SUA level in the 3 degree hypertension group was significantly higher than that in the 2 degree hypertension group(P<0.01), the SUA level in the 1 degree hypertension group was higher than the control group significantly (P<0.01).4. There is no significant difference in SUA between microal-buminuria and normal albuminuria group (p> 0.05); however, the level of SUA in macroalbuminuria group showed significant difference compared with microalbuminuria and normal albumin group (P<0.05)Conclusions:1. The serum uric acid concentration is positively related to the degree of hypertension, which indicates that the higher degree of blood pressure,the higher level of serum uric acid is.2. The serum uric acid level is partly associated with albuminuria, which shows early renal damages.