Survivin Gene Promoter-31C>G Polymorphism And Nasopharyngeal Carcinoma Risk Among Chinese

Aim:To investigage whether the-31C>G polymorphism was associated with the risk of occurrence and progression of nasopharyngeal carcinoma (NPC)Methods:Genotype SURVIVIN-31C>G in a Chinese case-control population from Guangxi, China (including 855 NPC patients and 1036 controls). Multivariate logistic regression analysis was used to calculate adjusted odds ratio (OR) and 95% confidence interval (CI).Results:We observed that compared with the genotypes containing G allele (CG+ GG genotype), the CC genotype was associated with significantly increased susceptibility to NPC occurrence, with an OR of 1.40 (95%CI 1.13-1.73; P= 0.0020). However, we did not observe any effect of the-31C>G polymorphism on progression of NPC (as measured by tumor-node-metastasis staging system) in the Guangxi population. Conclution:Our findings suggest that the-31C>G polymorphism may be a genetic risk factor for the occurrence of NPC among Chinese.