Sodium Alginate Microsphere+Iodized Oil Selective Arterial Embolization Primary Liver Cancer

Objective To observe the application of sodium alginate microsphere selective arterial embolization + lipiodol treatment of primary liver cancer. To explore the simple to the liver tumor blood vessels and artery embolism.Methods 89 patients with advanced liver cancer were randomly divided into three groups for intervention; A group: 27 patients received sodium alginate microspheres + iodized oil selective hepatic arterial embolization of tumor vessels and treatment; B group: 30 cases to alginate microspheres + mixture of iodized oil and chemotherapeutic agents of tumor blood vessels and selective hepatic artery embolization; C group: 32 cases, conventional TACE, chemotherapy drugs perfusion + mixture of iodized oil and chemotherapeutic agents selective hepatic tumor blood vessels and blood supply artery embolization; B, C groups with the same chemotherapy. Compared three groups of patients with hepatocellular carcinoma after interventional tumor necrosis, liver damage conditions and changes in AFP, and side effects, extent and 3 months, 6 months, 9 months in each group and the recent transfers of survival differences.Results The tumor necrosis rate: 4 weeks after A, B tumor necrosis two groups were higher than C group (P <0.05), but A, B no significant difference between the two groups; liver damage: among the three groups There was significant difference (P <0.05), the extent of damage were B> C> A group; AFP drop of: A, B no significant difference between the two groups (P> 0.05), but A, B group and C group have different level was lower than C group; postoperative side effects: The three groups of patients were abdominal pain, fever, A, B groups were higher than the C group (P <0.05), but A, B in two groups There was no significant difference (P> 0.05). A group of postoperative nausea, vomiting and decreased WBC light, B, C groups was higher than in the A group (p <0.05), but B, C between the two groups showed no significant difference (P> 0.05); surgery After the transfer case: A, B, C patients after 3 months, 6 months, 9 months metastasis rates were 7.4%, 11.1%, 18.5%, 6.7%, 13.3%, 16.7% and 9.3%, 15.6 %, 25.0%, A, B transfer rate between the two groups showed no significant difference (P> 0.05), but lower than C group (P <0.05). Recent survival: three groups of patients 6 months after treatment, no significant difference in survival (P> 0.05), after treatment, 9 months and 12 months, A, B group survival rate was higher than C group (P <0 .05), but, A, B between the two groups was no significant difference in survival rates (P> 0.05).Conclusion KMG is a convenient, safe and effective, the role of durable, biodegradable embolic agent. KMG + iodized oil selective arterial embolization of primary liver cancer, its efficacy is superior to TACE alone treatment with TACE + KMG selective arterial embolization of liver cancer was no significant difference in clinical efficacy, but its advantage is not to use chemotherapy can avoid chemotherapy drug toxicity and improve the patient's tolerance, is more suitable for weak constitution can not tolerate side effects of chemotherapy patients and broaden the embolization of primary liver cancer surgery Shi Ying Zheng, and embolization have been even more completely, can reduce the number of TACE. The efficacy of conventional TACE procedure depends on the choice of embolic agents and the degree of tumor-feeding artery embolization.