The Predictive Value Of Prostate Specific Antigen (PSA) Density In Diagnosis Of Prostate Cancer In Men With Gray-zone PSA Levels

Objective:To investigate the diagnostic value of prostate specific antigen density (PSAD) in detecting prostate cancer in men with serum prostate-specific antigen (PSA) levels of 4-10ng/ml.Methods:From January 2009 to December 2009, a total of 79 men with PSA levels of 4-10 ng/ml and biopsy proven prostate cancer or benign prostatic hyperplasia (BPH) were included in this study. Receiver-operating characteristic (ROC) curves were constructed to compare the diagnostic value of PSA level, free PSA/total PSA (f/tPSA) and PSAD in detecting prostate cancer.Result:Prostate cancer was diagnosed in 14 (17.72%) of the 79 men. There were significant differences between BPH group and prostate cancer group in the fPSA, f/tPSA, prostate volume and PSAD, whereas no significant difference in age and PSA level. The area under the curve (AUC) of PSAD (0.814) was significantly greater than that of tPSA (0.54) and f/tPSA (0.285). The sensitivity and specificity of PSAD at a cutoff of 0.14 ng/ml2 was 95%and 40%, respectively.Conclusion: PS AD was a better predictor of prostate cancer than f/tPSA in men with PSA levels of 4-10ng/ml.