Correlation Between Diffusion-weighted Imaging And Histopathologic State Of Rat Brain Of Severe Acute Alcoholism.

Objectiveto investigate the pathological system of coma,lethargy and even death caused by severe acute alcoholism by studying the brain iamge of DWI and relevent pathological changes on the rat models of severe acute alconolism.Methodsselect 16 male wistar rats, weight ranged from 140g to 150g. using self-control study。Divided into non alcohol injection group and severe acute alcholism group according to wether inject alcohol, severe acute alcholism group includes severe acute alcoholism survival group and severe acute alcoholism death group. All 16 rats beforeand after modeling underwent DWI and light microscope examination.。Resultsthere were no abnormal signals on DWI image of non alcohol injection group, and ADC value didn't change at different point of time. Compared with non alcohol injection group, severe acoholism live group showed high signal on DWI image, and ADC value showed decreasing trend with time. Abnormal high signal can also be seen on DWI image of severe alcoholism dead group, and ADC value showed a sudden drop in a short term. Histopathological examination revealed cytotoxic brain edema on severe acute alcoholism group, manifested as reduction in the number of astrocytes, nuclear pyknosis, protruding reduced or disappeared; nerve fiber deformation and loose reticular structure, some nerve fibers breakage; nerve cells smaller in size, deformation.Conclusionthe main brain complications due to acute alcoholism is cytotoxic brain edema, which is also the reason for coma, lethargy and death, the main pathological system is alcohol-induced brain hypoxic-ischemic change.