The Value Of The Apparent Diffusion Coefficient In The Assessment Of Perilesional Edema Character Of Different Brain Diseases

Objective:To prospectively assess the value of apparent diffusion coefficient (ADC) in the evaluation of perilesional edema character of different intracranial diseases (metastatic brain tumors, gliomas and inflammatory diseases).Methods:Seventy-six patients with brain diseases (30metastatic brain tumors,26gliomas (Ⅲ-Ⅳgrade glioma,21;Ⅱ grade glioma,5) and20inflammatory diseases) underwent routine and diffusion-weighted MR imaging, part patients also underwent enhanced MRI. The distance of perilesional edema was more than10mm, and was divided into two regions_immediate perilesional edema and distant edema, the ADC values were measured in the two regions of edema and in the healthy contralateral brain, and then the rADC values were calculated.Results:①There were significant differences in rADC values among the immediate perilesional edema of metastatic brain tumors(M), gliomas (G)and inflammatory diseases(ID)(rADC values(M)>rADC valueS(G) and rADC values (ID), F=3.12, P<0.05), but not in the rADC values among the distant edema (F=1.36, P>0.05).②The rADC values were significant between the immediate perilesional edema(IE) and distant edema(DE) of the metastatic brain tumors (rADC values (IE)>rADC values (DE), t=2.068, P<0.05), but not the gliomas and inflammatory diseases (tG=0.935, P>0.05;tID=-0.433, P>0.05).③And the rADC values were insignificant between inflammatory diseases and gliomas including the immediate perilesional edema and distant edema (tIE=-1.068, P>0.05; tDE=1.302, P>0.05).Conclusion:The rADC values have some value in the assessment of perilesional edema character of different intracranial diseases.