The Effect Of Nonsteroidal Anti-inflammatory Drugs At Different Administration Timing On Central Foveal Thickness Following Cataract Surgery

ObjectiveTo compare the different effect on central foveal thickness at different administration timing treated with NSAIDs following cataract surgery. To prospectively investigate the differences of admistration timing of NSAIDs between diabetic patients and patients with cataract only.MethodsNinety patients were divided into two groups randomly in this prospective, randomized study. Each group contains 23 patients(cataract combined with Diabetic disease) and 22 patients (cataract only). These patients were enrolled for cataract surgery from Feb.2009 to Sep.2009 without any postoperative complications. In groupⅠ(trial group), Pranoprofen was administrated one day before surgery in 45 eyes, and in groupⅡ(control group), Pranoprofen was administrated one day following cataract surgery in 45 eyes. All the patients were treated with Tobramycin and Dexamethasone one day after surgery. Central foveal thickness was detected by Optical Coherence Tomography (OCT) at the last week before surgery, the 7th day and the 30th day after surgery respectively.ResultsNo significant differences were found in central foveal thickness between groups at the 7th day after surgery, whereas there were significant differences in central foveal thickness between groups at the 30th day after surgery. There were no significant differences in central foveal thickness and retinal thickening of macular fovea in patients with cataract only between groups at the 7th day and the 30th day postoperatively. In the patients with cataract and diabetic disease, significant differences were found in central foveal thickness and retinal thickening of macular fovea between groups (P＜0.05) at the 7th day and the 30th day after surgery.ConclusionOur data demonstrated that there were no differences in central foveal thickness between preoperative and postoperative administration in patients with cataract only. However, in the patients with cataract and diabetic disease, Pranoprofen administrated preoperatively was testified to have better effects on alleviating retinal thickening of fovea centralis compared with that of postoperative administration. Our findings suggested that preoperative administration of Pranoprofen should be taken into account when we treat cataract patients with diabetic disease.