The Correlated Study Of Serum RBP4 Level In Chronic Hepatitis C

Background Retinol binding protein 4(RBP4) is a significant transport protein in vivo that take main responsibility to combine and convey VitA.To investigate the levels of serum retinol-binding protein 4 (RBP4) and related factors in chronic hepatitis C.Methods 56 patients with CHC and 35 Healthy volunteers wereselected. Serum levels of RBP4 were measured by ELISA method. Fasting blood glucose (FBG), triglycerides (TG),total cholester (TC), alanineaminotransferase (ALT), r-glutamyltranspeptidase (GGT) were measured, HCV-RNA levels were tested by qualitative polymerase chain reaction (q-PCR), Fatty liver disease were determined by sonography,BMI was calculated.Results Serum RBP4 levels in CHC group were higher than those in the normal group (33.38±6.43 VS 26.11±3.35μg/ml, P<0.01), the CHC patients with ALT normal had higher RBP4 levels compared with ALT abnormals (38.96±4.09 VS 28.5313.43μg/ml, P<0.001).The ALT levels in CHC patients are negatively correlated with RBP4 levels (r=-0.6368, P<0.05). Serum RBP4 levels in CHC were not associated with HCV-RNA..Conclusion Serum RBP4 levels were significantly associated with CHC and are negatively correlated with ALT levels, RBP4 were not associated with HCV-RNA..