Study Of The Relationship Between Adiponectin And Chronic Congestive Heart Failure

Objective:To investigate the relationship of APN with the cause of congestive heart failure through evaluate the plasma level of Adiponectin in various congestive heart failures; furthermore, through detect the serum level of APN, BNP and CRP in various severity of CHF patients and the change of the level before and after treatment of heart failure, to evaluate the effect of APN in CHF.Method:149 CHF patients were divided into coronary artery disease group (n=75) and non coronary artery disease group (n=74). All patients were also divided into heart function classⅡ, classⅢclassⅣgroup according to the New York Heart Association (NYHA) Functional Classification. There were 30 healty peoples consider as normal control group. All peoples were routinely received echocardiography, chest X-ray and biochemical test including APN, BNP and CRP. All patients were received the treatment of diuretic, ACEI andβ-blocker.Result:1. There was no statistical difference of basic characterics in CHF patients compared to control group (P>0.05)。There was significant difference of the level of plasma APN in each heart function classⅡ, classⅢand classⅣgroup (4.10±0.67μg/mL; 5.90±0.63μg/mL; 10.60±l.32μg/mL). Furthermore, there was significant difference of the level of plasma APN in each heart function class compared to control group(4.10±0.67μg/mL; 5.90±0.63μg/mL; 10.60±1.32μg/mL) (P<0.01). The level of BNP and CRP in each heart function class group was significantly higher than control group and the level of BNP and CRP in each heart function class group was also have significant difference(P<0.01).2. There was no significant difference of the level of plasma APN in heart function classⅡof coronary heart disease group (4.26±0.96μg/mL) compared to heart function classⅡof non-coronary heart disease group (4.51±0.37μg/mL) (P>0.05). There was no significant difference of the level of plasma APN in heart function classⅢof coronary heart disease group (6.0510.58μg/mL) compared to heart function classⅢof non-coronary heart disease group (5.77±0.64μg/mL) (P>0.05). There was no significant difference of the level of plasma APN in heart function class IV of coronary heart disease group (10.01±1.246μg/mL) compared to heart function class IV of non-coronary heart disease group (10.11±1.24μg/mL) (P>0.05).3. The level of plasma BNP, APN and serum CRP in each heart function class group was significantly increased through increasing of the severity of heart function (P<0.01). Linear correlation analysis indicated that the level of APN, BNP and CRP was positively correlated with cardiac function (r=0.886, P<0.01).4. The level of APN in heart function classⅢ(3.59±0.53μg/mL) was significantly decreased after treatment (6.04±0.65μg/mL) (P<0.01). The level of APN in heart function classⅣ(4.59±0.64μg/mL) was significantly decreased after treatment (9.98±1.28,ug/mL) (P<0.01)Conclusion:1. The level of plasma APN, BNP and CRP in CHF patients was increased through increasing of the stage of heart function. This result indicated that the level of plasma APN, BNP and CRP was correlated with the severity of heart failure and also used to evaluate the effect of treatment on heart failure.2. The level of plasma APN in CHF patients was not correlated with the casue of CHF.