Relationship Between Pepsinogen Ⅰ, Ⅱ, Gastrin-17 And Chronic Atrophic Gastritis

Background and aims:Currently the diagnosis of chronic atrophic gastritis are mainly by endoscopy and histopathology.In recent years,many studies have shown that serum pepsinogenⅠ(PGⅠ),(PGⅡ),serum gastrin-17 were associated with the CAG. This paper is to investigate the serum PGⅠ,PGⅡ,G-17 levels in the relationship with the endoscopic diagnosis the relevance of CAG, to establish it as a noninvasive clinical value of screening.Methods:80 hospitalized patients with chronic gastritis were selected from the department of Gastroenterology of the Second Affiliated Hospital of Dalian Medical University from October 2009 to April 2010.Each of them under went endoscopy with biopsies according to the Chinese consensus of chronic gastritis,2006,Shanghai.Another biopsy was taken for the rapid urease test for determination of H.pylori infection.These patients were further divided into two groups of non-atrophic gastritis group (45 cases) and atrophic gastritis group (35 cases) based on endoscopic and histological findings.All patients had taken 3 ml fasting venous blood in the morning, serum samples of PGⅠ,PGⅡ,G-17 were analyzed by enzyme-linked immunosorbent assay (ELISA).The data was analyzed by SPSS 11.5 statistical analysis software.T-test was used to analyze the difference of age between non-atrophic gastritis and atrophic gastritis,the difference of PGⅠ,PGⅡ,PGR,G-17 between non-atrophic gastritis and atrophic gastritis,the difference of serum PGⅠ,PGⅡ,PGR, G-17 between H.Pylori positive and negative group of non-atrophic gastritis were analyzed with T-test,P<0.05 was considered statistically significant. The difference of PGⅠ,PGR, G-17 among atrophic antral gastritis, atrophic corpus gastritis and atrophic pangastritis were analyzed with homogeneity of variance analysis,P<0.05 was considered statistically significant.The difference of positivity rate of H.Pylori infection in non-atrophic gastritis and atrophic gastritis was analyzed with Chi-square Test,P<0.05 was considered statistically significant.Results:1.PGⅠand PGR values were decreased in atrophic gastritis (74.27±21.8ng/ml,5.80±0.98)as compared with non-atrophic gastritis (91.58±27.14ng/ml,6.86±2.07).Patients with atrophic corpus gastritis (54.27±14.50ng/ml,5.02±0.99)and atrophic pangastritis(69.73±11.54ng/ml, 4.46±1.29)had low PGⅠand PGR values(P<0.05).2.G-17 levels were decreased in atrophic gastritis(299.70±125.60ng/l) as compared with non-atrophic gastritis(381.10±128.13ng/l).Patients with atrophic antral gastritis (260.54±106.83ng/l)and atrophic pangastritis (301.73±104.01ng/l) had low G-17 values when compared with atrophic corpus gastritis (P<0.05).3.The positivity rate of H. Pylori infection was 82% in the non-atrophic gastritis,and was 91% in the atrophic gastritis.The positivity rate of H. Pylori infection has no significant difference between the two groups.PGⅠ,PGⅡ,PGR, G-17 level have no significant difference in H. Pylori positive and negative group(P>0.05).Conclusion:1.Lower PGⅠ,PGR values are biomarkers of atrophic corpus gastritis.Lower G-17 values are biomarkers of atrophic antral gastritis.Serum PGⅠ,PGR, G-17 level were decreased in atrophic pangastritis.2.H. Pylori and the serum PGⅠ,PGⅡ,PGR, G-17 levels were not related.