Study On Esophageal Motility In Patients With Peptic Ulcer

Objective:To explore the changes of esophageal motility in patients with peptic ulcer (PU).Methods:30 Patients with PU and 20 healthy volunteers were selected in this study. All individuals who underwent esophageal manometry were determined lower esophageal sphincter pressure(LESP), lower esophageal sphincter relaxation pressure(LESRP),lower esophageal sphincter relax-ation rate (LESRR) and the amplitude and type of peristaltic contraction wave of the upper segment and lower segment of esophageal body. Meanwhile, with Rapid Urease Test and 14C-Urea Breath Test,we assessed the Helicobacter pylori (Hp) infection rate in the PU group. The patients who were all positive or negative were identified with or without Hp infection.Results:1. The test results of LESP,LESRP,LESRR in the PU group:LESP in the PU group was lower than that in the control group(8.19±4.68mmHgvs 19.83±6.11mmHg, P<0.05);LESRP in the PU group was higher than that in the control group(4.04±6.94mmHgvs1.42±1.28mmHg,P<0.05);LESRR in the PU group was lower than that in the control group(73.35±21.30%vs 90.81±9.27%,P<0.05).2. The test results of esophageal body motility in the PU group: Between the PU patients and healthy volunteers, there were no significant differences in the average amplitude of peristaltic contraction of upper segment of esophageal body (32.09±16.20mmHgvs48.57±15.37mmHg, P>0.05),the average amplitude of peristaltic contraction of lower segment of esophageal body (64.68±32.44mmHg vs69.01±29.67mmHg,P>0.05). 3. The type of esophageal peristaltic contraction wave in PU group: There were 16 abnormal peristalsis waves in the PU group. They showed bimodal waves, three-peak waves and non-conductive synchronous contr-action waves, etc. Synchronous contraction waves were the most in these waves, there were 14 cases. In addition, there were 11 cases of abnormal esophageal peristalsis have combined low-pressure peristaltic. The abnor-mality detection rate of esophageal body motion in the PU group is 53.33%.4. The test results of Hp in PU group:In PU group, the Helicobacter pylori (Hp) infection was 71.43%. In Hp-positive group versus Hp-negative, LESP(17.67±7.95mmHgvs18.89±6.68mmHg),LESRP(5.07±8.28mmHgvs1.9 1±1.95mmHg), LESRR(78.42±27.35%vs89.63±12.16%), the average amp-litude of peristalsis contraction of upper segment of esophageal body (33.29±15.59mmHgvs29.11±19.08mmHg), the average amplitude of peri-stalsis contraction of lower segment of esophageal body (61.79±32.46mm Hgvs 62.20±31.53mmHg), etc. All esophageal motility indexes were not significantly different between two groups(P>0.05).Conclusion:The abnormal esophageal motility could occur in the part of patients with peptic ulcer, mainly as follows:1. LESP in the part of patients with peptic ulcer were lower and their relaxations after swallowing were non-performing completely.2. The peristalsis contractions of lower segment of esophageal body in the part of patients with peptic ulcer were lower relatively.3. The abnormal esophageal motility could occur in the part of patients with peptic ulcer and could display in synchronous contraction waves, bimodal waves, and three-peak waves etc. The quantity of synchronous contraction waves in these abnormal peristalsis waves were the most.4. Helicobacter pylori infection may have no significant effect on the esophageal motor function in the patients with peptic ulcer.