The Expression And Clinical Significance Of Protein Gene Product 9.5 In Non-small Cell Lung Cancer

Background: Lung cancer is the most commonly fatal malignancy, it causes the greatest number of cancer death worldwide for all forms of cancer.Successful treatment of this disease depends on its early detection, but clinical detection of lung cancer usually occurs late in the disease .It have reported that the overexpression of PGP9.5 in cancer tissues may play an important role in the oncogenesis and development of lung cancer. The level of PGP9.5 raised in the developing process of lung cancer. This suggests that PGP9.5 is an important marker of lung epithelial transformation and carcinogenesis.Objective: To investigate the expression features and clinical significance of the protein gene product 9.5(PGP9.5) in non-small cell lung cancer.Methods: PGP9.5 expression of cancer tissues, paracancerous lung tissues was detected in 34 non-small cell lung cancer patients and pulmonary tissues in 7 patients with .benigh pulmonary lesions as control by immunohistoschemistry methods and fluorescence quantitative reverse transcriptase polymerase chain reaction.Results: The positive expressive rate of PGP9.5 in lung cancer tissue (64.71%) was significantly higher than those in paracancerous lung tissue(32.35%,p<0.05) and benigh pulmonary lesion tissues(14.29%,p<0.05),There was no relationship between PGP9.5 gene expression and gender, age, pathological subtype, differentiation grade, lymph.node.metastasis. PGP9.5 gene was preferentially expressed in T3/T4 NSCLC compared with T1/T2 NSCLC and expression of PGP9.5 is correlated with smoking in NSCLC.(p<0.05).Conclusion: The overexpression of PGP9.5 in cancer tissues may play an important role in the oncogenesis and development of lung cancer. Detection of PGP9.5 expression may be helpful to diagnose lung cancer and to predict prognosis of the patients with lung cancer.