Compared Study With Recombinant Human Brain Natriuretic Peptide And Milrinone In The Chronic Heart Failure With Acute Attack

Objective:To compare the recombinant human brain natriuretic peptide (rhBNP) and milrinone in the treatment of chronic congestive heart failure (CHF) with acute exacerbation. Clinical efficacy, cardiac function and serum brain natriuretic peptide (BNP) and norepinephrine (NE) levels were observed in two groups.Method:100 patients with acute exacerbation were randomized into rhBNP group(n=50) and milrinone group(n=50), clinical efficacy, heart function, changes in serum levels of BNP and NE were observed before and 48h after treatment.Results:Efficiency and the total effective rates in rhBNP group were higher than those in milrinone group (P<0.05), serum BNP and NE levels decreased in rhBNP group compared with milrinone group (P<0.05) 48h after treatment, after 2w of treatment EF values increase in rhBNP group (P<0.05).Conclusion:rhBNP can improve ventricular systolic function, delayed ventricular remodeling, and can be used in the CHF patients with acute exacerbation...