Changes Of Serum And Urinary SFlt-1 To PLGF Ratio In Preeclampsia Pregnant Women

objective:To investigate the changes of serum and urinary soluble fms-like tyrosine kinase-1( sFlt-1)to placental growth factor(PLGF) ratio in preeclampsia pregnant women, and to study the relationship between the levels and the degree of preeclampsia,and to identify whether the level of PLGF and sFlt-1 in urine is significantly correlative with those in serum .Methods :Women enrolled prospectively infollowing groups : women with mild preeclampsia(mPE,n=25),women with severe preeclampsia(sPE,n=20),and healthy pregnant control (CTR,n=20).The serum and urinary sFlt-1/ PLGF ratio were measured by enzyme linked immunoassay (ELISA),and to identify whether the level of PLGF and sFlt-1 in urine is significantly correlative with those in serum from 65 pregnant women .Results :The serum and urinary sFlt-1/ PLGF ratio in women with mPE compared with sPE and CTR groups were significantly difference (p<0.05).The urinary PLGF and sFlt-1 level were significantly correlative with those in serum.Conclusion :The degree of Preeclampsia is associated with the serum and urinary level of sFlt-1/ PLGF ratio.The sFlt-1/ PLGF ratio in urine may be used to study the connection between PE and sFlt-1/ PLGF ratio instead of serum sFlt-1/ PLGF ratio,and that can be used as a predictive marker for preeclampsia.The measurement of sFlt-1 in combination with PLGFmay distinguish women who subsequently develop preeclampsia from women who remain normotensive during pregnancy.