The Relationship Between Plasma Lipoprotein-associated Pospholipase A2 And Coronary Heart Disease And The Effection Of Different Dosage Of Atorvastain

BackgroundIt is indicated that coronary atherosclerosis disease (CHD) is a disease of chronic inflammation, inflammation plays an important role in the development and progress of atherosclerosis, and anti-inflammatory therapy comes a frontier of atherosclerosis prevention. Lipoprotein-associated pospholipase A2 (Lp-PLA2) is a inflammation factor, lots of studies showed that Lp-PLA2 increased in the atherosclerotic plaque, and is correlated to the stability. It is a independent risk factor of CHD. Statins has anti-inflammatory effect except for reduce blood fat. It also can stable plaque and improve prognosis of CHD.ObjectiveTo investigate the correlations between serum levels of lipoprotein-associated pospholipase A2 and the severity and stability of coronary atherosclerosis. To observe the influence of different dosage of atorvastatin play on plasma Lp-PLA2 of coronary artery disease patients.MethodsCoronary angiography (CAG) was performed in 86 patients who were suspected as having coronary artery disease(CHD). According to the coronary artery chanrges and plaque characters in CAG, all patients were divided into control group(n=24) and CHD group(n=62). According to the clinical types, the CHD patients were divided into acute coronary syndrome (ACS) group (n=42) and stable angina pectoris (SAP) group (n=20). According to the dose of atorvastatin, CHD group was divide into two groups in random, and was given 20mg and 80mg atorvastatin every night. The number of diseased coronary branches and Gensini's score is use for evaluate the severity of atherosclerosis. The clinical types is use for evaluate the stability of plaque. Lp-PLA2 and hs-CRP were measured in all the patients. The correlation between serum Lp-PLA2 with hs-CRP and the number of diseased coronary branches, Gensini's score, clinical types were analyzed. The CHD group were withdrawal one week later, determine the serum Lp-PLA2 level and hs-CRP. Compare the influence of different dosage of atorvastain.ResultsLp-PLA2 in CHD patients was significantly higher than that in control group(P<0.05) and increased with the increasing number of diseased coronary branches and Gensini's score. Lp-PLA2 in ACS group was higher than SAP group. Lp-PLA2 level had no correlated with hs-CRP. Lp-PLA2 level was lower in the patients were given 80mg atorvastatin than 20mg.ConclusionCHD patients serum Lp-PLA2 level is correlated with the severity of atherosclerosis and the stability of plaque. Take atorvastatins 80mg/d for one week could depress Lp-PLA2 and hs-CRP more than routine dose.