Contrast Analysis Of Serum Vitamin E And Markers Of Hepatic Fibrosis And Serum Biochemical In Patients With Liver Cirrhosis

ObjectiveTo study the relationship between serum vitamin E and markers of hepatic fibrosis and serum biochemical in patients with liver cirrhosis.Method133 liver cirrhotic patients (experimental group) and 33 healthy volunteers (control group) were included in the study. Serum vitamin E level was detected high performance liquid chromatography(HPLC). Meanwhile, blood biochemistry tests,were performed.ResultsBased on clinical manifestations and laboratory examinations,26 patients were classified as having Child-Pugh class A cirrhosis,73 as having Child-Pugh class B cirrhosis, and 34 as having Child-Pugh class C. The levels of serum vitamin E reduced and hepatic fibrosis markers increased gradually with the degree of clinical liver cirrhosis deteriorated. Compared with the control group, serum vitamin E decreased significantly(P=0.000) at Child-Pugh class A, B, and C in experimental group while hepatic fibrosis markers are on the contrary. GGT, TBIL increased and ALB decreased significantly(P<0.01). PTR decreased significantly(P=0.000) at class C and B, but not at calss A(P=0.063). Serum vitamin E was negatively correlated with HA, IV-C, LN, TBIL(P<0.05),and a positive correlation was found with ALB,PTA (P<0.01) in experimental group. There was no correlation between vitamin E and markers as PC-â…¢, ALT, AST, GGT, ALP(P>0.05).ConclusionsThere were relationship between serum vitamin E and markers of hepatic fibrosis and serum biochemical in patients with liver cirrhosis. Measuring the concentration of serum vitamin E and markers of hepatic fibrosis and serum biochemical has utilizable and reliable clinical value in predicting the degrees and prognosis of liver cirrhosis.