The Detection And Clinical Significance Of High Sensitive C-reactive Protein In Patients With The Acute Coronary Syndrome

[Objective]To analyze the correlation of severity of ACS coronary artery disease and the levels of serum hs-CRP, and explore its clinical significance by comparing the levels of hs-CRP of acute coronary syndrome (ACS) and normal healthy patients.[Methods]48 cases of ACS were divided into 24 cases of unstable angina pectoris(UA group) and 24 cases of acute myocardial infarction(AMI group).25 cases of the normal healthy people were as control group. The serum content of hs-CRP was measured with enhanced immunoturbidimetric assay(ITM). Cardiac enzyme and blood lipid were also measured. Coronary angiography was performed in all ACS patients.[Results]Serum level of hs-CRP and LDL-C in UA group and AMI group were significantly higher than those in control group. Serum level of HDL-C in UA and AMI patients were significantly lower than those in control group. Serum levels of CK and CK-MB in AMI group were significantly higher than those in control group and UA group. The level of hs-CRP in double-artery lesions group and multi-artery lesions group were significantly higher than that in single coronary disease group(P<0.01).The level of hs-CRP in two coronary disease group was significantly higher than that in three coronary disease group(P<0.01). Pearson relation analysis showed that hsCRP level was positively correlated with the severity of coronary artery stenosis in ACS patients(P=0.000*,r=0.996).[Conclusion]1.Combined detection of hs-CRP with cardiac enzyme and blood lipid was significant to diagnose unstable angina pectoris(UA) and acute myocardial infarction(AMI).2. Hs-CRP was an important diagnosis index for the inflammation of atherosclerosis, which may show the severity of coronary artery stenosis.