| Objective:1.To study the difference on the ventricular diastolic function of hypertensive and normal human by Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI).2.To study the correlation between the traditional two-dimensional echocardiography (2DE) and Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI) when they evaluate the left ventricular diastolic function.3.To study the different effect of the ventricular diastolic function of hypertensive who are after or before treated by Integrated traditional Chinese and Western medicine or Western medicine only by Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI).4.To study the different effect of the ventricular diastolic function of hypertensive who are treated by Integrated traditional Chinese and Western medicine or Western medicine only by Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI).Methods:1.The study population is consisted of 40 hypertensive patients (20 men,20 women)without other cardiac diseases and systemic disorders, and 20 age-and gender-matched normal volunteers(control group,11 men,9 women). All subjects were in sinus rhythm and showed no abnormalities on ECG. For all, grey-scale 2D echo images showed normal cardiac function on visual inspection. The hypertensives were randomly divided into 2 groups based on the order:group A and group B. The group A were treated by the Integrated traditional Chinese and Western medicine and the group B were conventionally treated by medicine. All of them had been treated with one month.2.The echocardiographic examinations were performed with a Philips iE 33 scanner equipped with a 3 MHz phased array transducer. For data acquisition, four complete cardiac cycles were collected and stored in a cine-loop format. Data were acquired with the subjects at rest, lying in the left lateral supine position. General echocardiographic parameters were measured:end diastolic volume (EDV), end systolic volume (ESV) and derived ejection fraction (EF) of the left ventricular; Blood pool pulsed Doppler recordings was obtained from the mitral valve inflow which were used to measure the following Doppler flow parameters:the peak velocity of E and A waves, the E/A ratio and the deceleration time of the E wave (DT). Blood pool pulsed Doppler recordings were obtained from the pulmonary vein which were used to measure the following Doppler flow parameters:Pulmonary Vein atrial reversal flow velocity (PVa), Pulmonary Vein diastolic flow velocity (PVd), Pulmonary Vein systolic flow velocity (PVs).3.To measure the Left Ventricular Mass(LVM), Left Ventricular End-Diastolic Volume (EDV), Peak filling rate (PFR), regional end-diastolic volume (rEDV), regional peak filling rate (rPFR) and regional stroke volume (rSV) of group C and before or after treatment of the group A and B by real-time three-dimensional echocardiography (RT-3DE).4.To measure the peak myocardial sustained early diastolic velocity (Ea) and peak myocardial sustained late diastolic velocity (Aa) of group C and before or after treatment of the group A and B by Tissue Doppler Imaging (TDI).5.To measure the myocardial sustained early strained velocity (mSRe) and myocardial sustained late strained velocity (mSRa) of group C and before or after treatment of the group A and B by Strain rate imaging (SRI).6.To measure the Peak filling rat (PFR), Tissue move ahead duration 1(TMAD1), Tissue move ahead duration 2(TMAD2), Tissue move ahead duration midpt (TMAD Midpt), Peak myocardial sustained early diastolic velocity (Ve), Peak myocardial sustained late diastolic velocity (Va) of group C and before or after treatment of the group A and B by Quantitative tissue velocity imaging (QTVI).7.Results are reported as means±standard deviations. Differences in continuous variables between 2 groups were assessed using the t-test, The Pearson correlation coefficient(r) was used to measure the strength of the association between the parameters, All data analysis was performed using statistical analysis software packages SPSS 17. Results:1.There are difference on the Left ventricular mass, Left ventricular massindex, Peak filling rate and Peak ejection rate of the group A and C. (P<0.01).2.Part of 17 segments rSV, rEDV and rPFR were significantly different on the group A and C. (P< 0.05).3.Ea, Aa and Ea/Aa were significantly different on the group A and C. (P＜0.01).4.MSRe, mSRa and mSRe/mSRa were significantly different on the group A and C. (P<0.01).5.PRF, TMAD1, MAD2, TMAD Midpt, Ve, Va and Ve/Va were significantly different on group A and C. (P＜0.01).6.PFR had significantly negative relation with E/A.(r=0.962,P<0.01). Ea/Aa had significantly negative relation with E/A. (r=0.978,P<0.01). MSRe/mSRa had significantly negative relation with E/A.(r=0.957,P<0.01). PRFR, Ve/Va, TMAD Midpt had significantly negative relation with E/A. (r=0.323,P<0.05,r=0.961,P<0.01, r=0.434, P＜0.05).7.There are difference on the left ventricular diastolic function of hypertensions which are before and after treated in the group A.(P<0.05).8.There are indifference on the left ventricular diastolic function of hypertensions which are before and after treated in the group A.(P>0.05).9.There are difference on the part of left ventricular diastolic function of hypertens-ions which are after treated in the group A and B. (P<0.05).Conclusions:1.There have a difference between the ventricular diastolic function with the hypertensions and normal human and they may clinical by Real-time three-dimensional echocardiography (RT-3DE), Doppler tissue imaging (DTI), Strain rate imaging (SRI) and Quantitative tissue velocity imaging (QTVI).2.Normal and patients with left ventricular hypertrophy of regional left ventricular myocardial diastolic has heterogeneity. RT-3DE provides a new method in assessing the regional left ventricular function.3.The treatment with Integrated traditional Chinese and Western medicine is more advantaged than the western medicine only.
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