The Clinical And Experimental Study For Intervening Inflammatory Factor And Protecting The Function Of Islet Beta-cell With Chinese Medicine

Objective:To observe the curative effect of nterening inflammatory factor and protecting islet beta-cell with chinese medicine.Method:the clinical study:61 cases of type 2 diabetes patients were randomly divided into treatment group (basic treatment+Jian Pi Gu Yi Tang), the control group (basic treatmentand+rosiglitazone), treatment for 8 weeks.We observe the change of clinical symptoms, signs and laboratory indicators and make the appropriate statistical analysis. The experimental study:the rat model of type 2 diabetes developped at beginning were randomly divided into five groups (normal group, model group, group lof Chinese medicine, group 2 of Chinese medicine, rosiglitazone group).After 6 weeks of drug intervention, draw blood and pancreas organizations to observe the change of general situation, glucose, lipid metabolism, pancreatic function, inflammatory factors and the morphology of islet.Result:the result of clinical study:1. The total effective rate of treatment group was 87.87%,and the control group was 60.71%,there were significant difference between the 2 groups(P<0.05).2.The treatment group had a good effect in curing glucose and lipid metabolism, the difference between the two groups is a little significant.3. In reducing inflammation factor, the treatment group showed better efficacy after stratifying the glucose level, and there were significant differences.4. The treatment group had a good effect in raising the plasma insulin and improving islet cell function,but not just as the control group.the result of the experimental study:1. The treatment can significantly reduce type 2 diabetes model rats polydipsia, Polyphaga, polyuria and overweight.2. The treatment group in improving glucose and lipid metabolism had little difference with the control group.3.the group 2 of Chinese medicine had a better effect in reducing the level of inflammatory factor,which had significant difference between rosiglitazone group. (P<0.05).4.The treatment group, especially high-dose group of Chinese medicine can effectively protect the islet (3-cell morphology. Conclusion:This study has enriched the theory of Chinese medicine on intervention inflammatory factors and protecting islet (3-cell function.Affirmed the effect"tonifying spleen and consolidation of origin, detoxicate and activating blood" of Jian Pi Gu Yi Tang, in order to lay a foundation for future in-depth study.