The Roles Of STREM-1 And PCT In The Diagnosis Of BP And IPIF

ObjectiveTo investigate the roles of Soluble Triggering Receptor Expressed on Myeloid cells-1(sTREM-1) and procalcitonin(PCT) as markers of infection in bacteria pneumonia (BP) and invasive pulmonary fungal infections (IPIF), the serum levels of sTREM-1 and PCT in patients with BP and IPIF were detected and analyzed, meanwhile, other inflammatory markers were also compared.MethodsTotal of 40 patients with BP,15 patients with IPIF,20 patients with pulmonary tuberculosis were enrolled in this study, and 30 normal persons served as controls.The following groups were defined:(1) BP group(n=40); (2) IPIF gurop(n=15); (3) TB group(n=20); (4) normal control group (n=30). Serum samples of all patients and control groups were collected. BP and IPIF patients were reexamined after treatments. Serum levels of sTREM-1 and PCT were measured by ELISA. Meanwhile, white blood cell (WBC) were counted and classified, and erythrocyte sedimentation rate (ESR) and C-reactive protein(CRP) were also determined.Then the levels of sTREM-1, PCT and other parameters were statistical analysed. ResultssTREM-1 concentration were, BP group 55.8(51.0)ng/L, IPIF group 53.0(94.2) ng/L, TB group 34.6(19.0) ng/L, and normal control group 33.5 (4.2) ng/L respectively. PCT concentration determination were, BP group 519.7(145.5) ng/L, IPIF group 504.9(493.6) ng/L, TB group 440.6 (126.8) ng/L, and normal control group 463.9 (36.1) ng/L, respectively. sTREM-1 and PCT concentrations were higher in BP and IPIF group than in TB and normal control group (p<0.05), but there was no significant difference between BP and IPIF group, TB and normal control group (p>0.05). Significant differences were observed in the sTREM-1 concentration between samples before and after treatment in the BP and IPIF patients (55.8(51.0) ng/L vs.41.8 (33.7) ng/L in the BP patients, and 53.0 (94.2) ng/L vs.42.1 (54.5) ng/L in the IPIF patients, P<0.05); Significant differences were also observed in the PCT concentration between samples before and after treatment in the BP and IPIF patients (519.7(145.5) ng/L vs.498.6 (90.0) ng/L in the BP patients, and 504.9(493.6) ng/L vs.485.7 (170.9) ng/L in the IPIF patients, P<0.05); There were no significant difference in the CRP concentration among BP and TB group(44.6(47.0)mg/L and 39.7(44.4) mg/L, respectively,P>0.05), while CRP concentration significantly increased in both of the groups compared with IPIF and normal control group (18.5 (59.7) mg/L,0.5 (0.4) mg/L, p<0.05), and slso increased in IPIF group compared with normal control group (p<0.05).White blood cell (WBC) count showed no difference between BP group and any other group (p>0.05), and also between IPIF and TB group (p>0.05); WBC count significantly increased in both IPIF and TB group compared with normal control group (p<0.05). The erythrocyte sedimentation rate showed no difference among the groups (p>0.05).ConclusionsSerum sTREM-1 and PCT levels are significantly higher in BP and IPIF patients than in normal population, while there is no difference between TB patients and normal population; serum sTREM-1 and PCT levels significantly decrease after therapy in BP and IPIF patients;detection of serum sTREM-1 and PCT levels don't contribute to the distinguish between BP and IPIF;detection of serum sTREM-1 and PCT may play important roles in the diagnosis of BP and IPIF.