Study On Physiological Function Of Kumquat Total Flavone

Kumquat (Fortunella Swingle) is rich in flavone, volatility oil, limonoids, edibility fibre and many kinds of vitamin. It has many kinds of physiology effect such as reduce cholesterin, lower blood pressre, improve immunity. But, up to now, there were no people study on it, this encumbranced the kumquat industrial exploiture at a certain extent. This paper would study on the physiology effect of kumquat total flavone, the accomplishment of this study would provide the theoretic aegis for exploiture kumquat and accelerate kumquat industrial exploiture.In this paper, kumquat total flavone was used as material, mice as experiment object, discussing the effect of different locality kumquat (Hunan Liuyang and Jiangxi Suichuan, the breed is Fortunella Crassifolia Swingle) to the physiology effect of kumquat total flavone. According to body weight, the paper put up three doses:20 mg/kg-bw,80 mg/kg-bw,160 mg/kg-bw, mealwhile, set up blank group and model group. The main study contents and results as follows:The anti-oxidative and anti-decrepitude effect of kumquat total flavone was studied, through evaluating the content of SOD and MDA in serum, living life-span, average life-span and Max. life-span. The results shown:compared with model group, the experiment groups could obvious prolong the life-span of mice. The two middle doses had markedness (P<0.05) effect to SOD, MDA and average life-span, the two higher doses had greatly markedness(P<0.01) effect.The moderating hyperlipaemia of kumquat total flavone was studied, through evaluating content of TC, TG and HDL-C in serum, the index of arteriosclerosis. The results shown:compared with model group, the middle and higher doses of Liuyang Kumquat had markness effect(P<0.05) (except for TG), the middle and higher doses of Yangshuo Kumquat had greatly markness effect(P<0.01) (except for TG). The two middle doses had markness effect to TG(P<0.05), the two higher doses had greatly markness effect to TG(P<0.01).The regulating blood suger effect of kumquat total flavone was studied through evaluating the kumquat total flavone to the diabetes mice' blood suger, glucose endurance and the normal mice'blood suger. The results shown:compared with model group, after 6 days, the two higher doses had markness effect(P<0.05) to the diabetes mice' blood suger, after 17 days, the two middle doses had improving glucose endurance, mealwhile, the two higher doses had greatly markness effect (P<0.01) to the diabetes mice' blood suger. But, all doses had no effect to the normal mice.The effect of kumquat total flavone on the immunity system was studied, through evaluating the phagocytic function of monocyte macrophage, the ear tumefaction induced by DNFB, swimming time, capacity of lacking of Oxygen, the index of thymus and spleen. The results shown:compared with model group, the two middle doses had markness effect(P<0.05), the two higher doses had greatly markness effect(P<0.01).The anti-microbial and security of kumquat total flavone was studied, through evaluating the anti-microbial of kumquat total flavone to E.col and Staphylococcus aureus and maximal tolerance dose test. The results shown:compared with model group, the kumquat total flavone had obviously restrain effect to E.col and Staphylococcus aureus and the maximal tolerance dose was 600 times more than human' absorbtion.The effect of kumquat total flavone on the gastrointestinal absorption function was stydied, through evaluating the stomach vacuation, small intestine movement rate, small intestine absorption function. The results shown:compared with model group, the two middle doses had markedness effect(P<0.05), the higher doses had greatly markedness effect(P<0.01). This shown that the kumquat total flavone could improve the gastrointestinal absorption function.From the study above, the conclusion was got that the kumquat total flavone had anti-oxidative, moderation hyperlipaemia, regulation blood suger, improvement immunity, anti-microbia, promotion gastrointestinal absorption function, it is a kind of very safe function ingredient and the growth entironment had prodigious effect to the physiology effect.