Effect Of Atorvastatin On The Vascular Endothecium Of Patients With Hyperlipaemia

Recent research shows that the vascular endothecium has played a vital role in regulating the cordis circulation and stabilizing the milieu interne. Vascular endothecium is an active apparatus with multiple physiological functions. Maladjustment of endothecium mainly manifests the abnormity of brachial endothelium - dependent diastolic function and the increase of conglutination. The mal -function might not only initiate the arteriosclerosis, but also urge on the evolve-ment of the disease. Therefore, to ameliorate and to restore the function of vascular endothecium has been an important goal during the treatment of coronary heart disease. Researches show that mal - function of vascular endothecium is an obvious symptom of patients with mixed hyperlipaemia before the porridge -shape arteriosclerosis, and the mal - function is a hazard inducing coronary heart disease independently. Atorvastatin has a great effect on the treatment of porridge - shape arteriosclerosis with various orientations and in multiple aspects. Apart from the function of lipemia regulation, Atorvastatin possesses many other functions, such as protection over endothecium, anti - inflammation, and stabilizing mottles. This research and investigation aims at observing the effect of Atorvastatin on the vascular endothecium of patients with mixed hyperlipaemia , and to further probe into the mechanism of Atorvastatin against porridge - shape arteriosclerosis.ObjectiveTo observe the influence of lipid - regulating treatment on the brachial endothelium - dependent diastolic function of patients with mixed hyperlipaemia, and the variation of the content of Endothelin within the plasma, and to clarifythe effect of Atorvastatin on the function of vascular endothecium.Methods60 patients with mixed hyperlipaemia were treated with Atorvastatin for 8 weeks (p. o) . Blood lipids and plasma ET were measured, and change of baseline of brachial angiobore and reactive hyperemia were also measured by Doppler ultrasound before and after treatment. The measurement was compared with the corresponding indices of peer group comprising 40 people whose blood - lipids are normal. The aforesaid indices are only measured once for the peer group.ResultThe vascular endothelium - dependent diastolic function of the patients with mixed hyperlipaemia was obviously damaged ( P < 0. 001) compared with the peer group. But there was no difference in the responses to nitroglycerin between the two groups (P > 0.05 ) , and plasma was increased remarkably ( P < 0.01). Endothelin, serum TG, TC, LDL - C of the patients with mixed hyperlipaemia obviously decreased after treatment with Atorvastatin for 8 weeks, the HDL- C increased remarkably (P < 0. 01 ) , and brachial artery vascular endothelium -dependent diastolic function witnessed a tremendous improve ( P < 0. 01 ), which shares no inter - relation with the decrease of TG, TC and LDL - C ( r = 0. 139,0. 164,0. 119, P >0. 05). The dependent diastolic function of brachial angiobore endothecium and the Endothelin are negatively correlated ( r = 0-0.864).DiscussionThe research has adopted the ultrasound, initiated by Celermajar, to measure the change of baseline of brachial angiobore and plasma ET in order to assess the function of vascular endothelium. Active hyperaemia stimulates the endothelium cell to release NO by means of promoting hobsinking power, resulting inthe dilation of vascular, which reflects the endothelium - dependent diastolic function (EDD). Nitroglycerin releases NO directly resulting in the dilation of vascular, which reflects the endothelium - independent diastolic function ( EI-DD). The research indicates that endothelium - dependent diastolic function of brachial angiobore introduced by blood is decreasing in the case of patients with mixed hyperlipaemia ( P <0. 01). Atorvastatin is able to improve the endothelium - dependent diastolic function of patients with mixed hyperlipaemia ( P < 0.01) , which is independent from its lipid - lowering function. The result acc...