Dynamic Change And Clinical Significance Of IGG Contents Of Crebrosprinal Fluid In Patients With Severe Traumatic Brain Injury

Background Secondary immune function changes Often appeared in patients with severe traumatic brain injury and influenced the patients'prognosis.Due to lack of simple and objective indicators,the judgments of patients'condition with severe traumatic brain injury often had very large differences.IgG contents in CSF of patients with severe traumatic brain injury were measured and then compared with the patients' condition. In this way, we could try to understand the relationships between IgG contents in CSF of patients with severe traumatic brain injury and their prognosis.Objective To explore the dynamic change of cerebrospinal fluid (CSF) IgG contents in patients with severe traumatic brain injury and its clinical significance.Methods IgG contents were measured serially for one week after hospitalization by using the enzyme linked rate nephelometry method in the CSF of 30 patients with severe traumatic brain injury, and comparative analysis combined with GCS scores on admission and the short-term and long-term prognosis of the patients were performed. Reszults Compared with the normal control group, the CSF levels of immuloglobin in the patients with severe head injury increased obviously on day 3, 5 and 7 after trauma (P<0.05,P<0.01, P<0.01, respectively). CSF immuloglobin levels on day 3 and 5 after injury of patients with GCS scores of 3～5 were significantly higher than those with GCS scores of 6～8(P<0.05). CSF immuloglobin levels on day 3 and 5 after trauma of the patients who died at 1 month after trauma were significantly higher than the survivals (P<0.05, P<0.01, respectively).Compared with the better prognosis group at 6 months after injury, the CSF levels of immuloglobin on day 5 and 7 after injury were significantly higher in poorer prognosis groups (P<0.05,P<0.01, respectively).Conclusion IgG contents in CSF of patients with severe traumatic brain injury increased obviously within 1 week after injury, and its dynamic change may have some clinical significance on the judgment of brain injury severity and the assesment of prognosis.