Effect Of Awareness On Anxiety, Depression And Changes Of Anxiety, Depression And Endocrine Hormone Before And After Chemotherapy In Patients With Cancer

【Objective】:(1)To explore the effect of awareness on anxiety, depression in patients with cancer. (2)To determine the effectiveness of club-pattern social support on the Psychological debugging of cancer patients. (3)To examine the changes of anxiety, depression before and after three cycles chemotherapy and effects on thyroid hormone, adrenocorticotrophic hormone, cortisol.【Mthods】:60 cancer inpatients before and after three cycles chemotherapy were assessed with self-edited schedules,self rating depression scale(SDS), self rating anxiety scale(SAS) and Hospital Anxiety and Depression Scale (HADS), were used to evaluate patient's awareness and mental conditions. The levels of serum thyroid hormone(TT3, TT4, FT3, FT4, TSH ),adrenocorticotrophic hormone(ACTH), cortisol(COR) were measured by Radioimmunoassay(RIA) methods respectively before and after three cycles chemotherapy. Totally 38 members of cancer rehabilitation club were also assessed.with the same self rating scales.【Results】:(1) Of the 60 cancer inpatients, 30 were full informed and 30 were partial informed. No significant difference in the standard scores of SAS, SDS, HADS was found between the full informed and the partial informed (P>0.05).(2)Awareness of breast cancer inpatients was significantly lower when compared with club members(47.5%vs86.8%, P=0.000), however, breast cancer inpatients had higher median HADS(A) scores(6±9vs3±5, P=0.025) and higher median HADS(D) scores than club members(5±10 vs1±2,P=0.006). (3)There were no significant differences in the scores of SAS, SDS, HADS and the FT4,TSH,COR levels before and after three cycles chemotherapy(P>0.05). But a significantly low serum TT3, TT4, FT3, ACTH levels of cancer inpatients was found after three cycles chemotherapy(P<0.05).【Conclusions】:Awareness(full informed , partial informed) had no significant effect on anxiety, depression in patients with cancer, and to some extent better awareness had no significant effect on cancer patients's anxiety, depression as well; awareness of club members and the scores of anxiety, depression were better than breast cancer inpatients, club-pattern social support might promote the the Psychological debugging of cancer patients; the serum TT3, TT4, FT3, ACTH levels of cancer inpatients decreased after three cycles chemotherapy. It demonstrated that surveying and protecting the fuction of endocrine glands was required in clinical practice.