Guangxi Liver High-risk Groups Queue Establishment And Database Construction

Background Hepatocellular carcinoma (HCC) is the effect of carcinoma, the region of guangxi people health major malignant tumor, in the region of guangxi its incidence and mortality are relatively high. The national third residents survey data show, cause of death by guangxi residents cancer-related mortality in the 1970s 38.29/10 million, up to 110.56/100,000. At present, guangxi cancer incidence reaches 6 million/year, including more than 50,000 people a year die because of malignant tumors. Malignant tumor of already by guangxi all rose to cause the first. Among them is 24 people in guangxi liver cancer mortality per 100,000 in malignant tumor, the first death. Therefore for liver cancer pathogenesis, new treatment technology research is of great significance.Purposes First, the establishment of liver cancer in Guangxi high risk cohort and epidemiological investigations and other related information database. Second, figure out a set of feasible and social and economical benefit good high-risk groups queue construction plan. Three, for cancer early, enhance the publicity scheme conducted the health knowledge level. Four, establish and perfect the detailed information lays zone, and the crowd database development completed front deployment.Methods Follow the study of voluntary principles for the Yulin, Cangwu the scene of high liver cancer over the age of 18 permanent residents mobilized to carry out screening, health knowledge missionary, epidemiological investigation, and two pairs of semi-serum hepatitis B screening. Epidemiological investigation by trained investigators using a specially designed questionnaire on the study subjects, including personal health, lifestyle and family situation. Including hepatitis B surface antigen (HBsAg) and core antibody (HBcAb) were positive for the object as a high risk of liver cancer cohort members were followed up in this high-risk groups on a regular basis and review. Review included abdominal ultrasonography and serum hepatitis B B two pairs of semi, liver function, alpha-fetoprotein (Armour fetal protein, AFP) and other biochemical parameters, review the objects were collected on all blood, separation of serum, plasma, placed - 20℃refrigerator. Screening data needed at the scene to establish the epidemiological survey software files, all information required for quality control, and input a database specifically designed for this study, post-data statistical functions using EXCEL 2007, SPSS 16 statistical analysis software.Results (1) has now completed 2376 of liver cancer at high risk cohort, covering the base population 22,897 people. Yulin area in which the basis of population 13,966, of whom 1,100 hepatitis B surface antigen positive, the positive rate of 7.88%; Northern Rivers region 1220 based on population, the positive number 172, the positive rate was 14.10%; Cangwu crowd 7711 people on a regional basis , the positive number of 1104 people, the positive rate of 14.3%. We collected all the study found the blood samples and completed questionnaires.(2) November 2, 2009 to November 9, 2009 Cangwu region were reviewed at high risk of liver cancer, the actual participants in 698 people, average age 41.96±9.08 years, 60 of them with abnormal ALT, AST abnormal were 36, AFP 26 positive, B-ultrasonic examination of liver abnormalities in 84, which found that liver function, AFP and B-3 were abnormal. April 2010 Cangwu areas of high-risk groups again were followed up and found a new HCC patients.(3) January 13, 2011 to April 31, 2011 were at high risk of liver cancer in Yulin area review, the actual average age of participants was 38.79±12.42 years of age, in which 198 people with abnormal ALT, AST 136 abnormal people, AFP positive 8, B-110 examination of liver abnormalities, liver function, AFP and B-4 were abnormal.(4) high risk of liver cancer were followed up initially to build a sound database, data table contains a total of 5, and its applications in practice have been applied to the countryside.Conclusion The establishment of liver cancer at high risk cohort is a long-term sustainability of the work. After two years of the study in Cangwu, Yulin has initially established a certain amount of liver cancer at high risk, high-risk groups based on blood samples library and information database for the next step to carry out high-level, high level and quality of the etiology of liver cancer of built specimens, data sharing platform, initially established with a certain scientific and universal data management system, the progressive realization of the high-risk groups, blood samples and data in scientific and effective management.Digital information will be at high risk, information systems for monitoring the efficiency of the liver, high-risk groups established queue data systems, making this project has been flexible in technical terms. We gradually Cangwu, Yulin worked out a set of feasible, economic, social well-building programs for high risk cohort, and timely screening points to the promotion of the region. In the scene of the early diagnosis and early treatment of liver cancer awareness and to mobilize a high-risk groups to participate in review and enhance population health knowledge.