Effect Of Propofol On Myocardial Injury In Rats Induced By Acute Liver Ischemiareperfusion And The Role Of PI3K/Akt Signaling Pathway In The Effect

ObjectiveTo investigate the protective effect of propofol on myocardial injury in rats induced by acute liver ischemia reperfusion and the relationship between the effect and PI3K-Akt signaling pathway.MethodsOne hundred and two male SD rats were randomly divided into five groups:sham,I/R,P,P+LY,P+DMSO group.The cardiac tiss samples of each group was prepaired for determination of the expression of signal protein of PI3K-Akt system,such as t- Akt and p- Akt,by means of wester-blot.ResultsCompared with the Sham group,other groups of myocardial p-Akt expression and apoptosis rate increased,P+LY group the expression of Bcl-2 was no significant difference (P>0.05),other groups were significantly higher(P<0.05); and I / R group, P myocardial p-Akt and Bcl-2 upregulation, cardiomyocyte apoptosis rate decreased (P <0.05), P + LY myocardial p-Akt, Bcl-2 expression and myocardial apoptosis rate was no significant difference (P> 0.05), P + DMSO myocardial p-Akt and Bcl-2 upregulation, cardiomyocyte apoptosis rate decreased (P <0.05); with the P group, P + LY myocardial p-Akt and Bcl-2 expression decreased (P <0.05), apoptosis rate increased (P <0.05), P + DMSO group of p-Akt, Bcl-2 expression and no difference in apoptosis rate statistically significant (P> 0.05).ConclusionPopofol could relieve rats'cardiac injury which comes from liver ischemia reperfusion.The protective effects are might relationship with up-regulating the activation of PI3K-Akt signal pathway.