The Expression And Amplification Of CerbB-2 Oncogene In The Gastric Adenocarcinoma And Its Significance

Objective:To investigate the significance of CerbB-2 oncogene in the occurrence and development of gastric adenocarcinoma.Methods:By using immunohistochemistry and fluorescence in situ hybridization, 60 cases of gastric adenocarcinoma tissue, 60 cases of the normal margin of mucosal tissue and 30 cases of normal gastric mucosa tissue were detected the expression and amplification of CerbB-2.Results:The positive rate of CerbB-2 expression in gastric adenocarcinoma tissues,normal margin of mucosal tissues and normal gastric mucosa tissues were 31.7%,8.33% and 3.33%; The positive rate of CerbB-2 amplification of these were 28.3%, 5% and 0%. There were significantly differences between gastric adenocarcinoma tissues and the others in the expression and amplification of CerbB-2.And the expression and amplification of CerbB-2 in gastric adenocarcinoma tissues had no correlation with age,gender,tumor size or tumor differentiation degree of patients'(P>0.05).But which were correlated with the extent of tumor invasion,lymph node metastasis, distant metastasis and clinical stage(P<0.05).Conclusion:CerbB-2 is closely related to the occurrence and development of gastric adenocarcinoma,and can be considered as important index for determining the biological behavior of gastric cancer.