Effects Of PTH (1-34) Treatment In 25 Postmenopausal Women With Osteoporosis

Objective25 postmenopausal women with osteoporosis received PTH(1-34) treatment for 12 months and we observed whether they fractured during the study process and measured spine(L1-4) BMD and left femoral neck BMD at baseline,6 months and 12 months of the study in order to study the effects of PTH (1-34) on PMOP.MethodsTwenty-five women (age 49 to 79 years,mean age 65.40±8.42 years),who were diagnosed as PMOP by DEXA in The First Affiliated Hospital of Shanxi Medical University from 2009 june to 2010 february were enrolled in our study. Selected standard:(1) 46～79 year-old female who were above natural menopause 2 years. (2) BMD was 2.5 more standard deviations below normal peak bone mass at L1-L4 or left femoral neck. (3) They were informed consent and signed voluntarily. They received PTH (1-34) 20μg, CaCO3 1250mg and vitamin D200IU daily in 12 months. Before the treatment, treats 6 months and 12 months later, patients were tested L1-L4 and left femoral neck BMD by DEXA. The data analyzed with repeated measures were evaluated whether the differences were statistically significant.ResultsAll patients did not fracture during the study process. In the test ofα=0.05 level, repeated measures was used for statistical analysis of data. (1) Comparing the BMD values at baseline and after 6 months, the differences between before and after their own at LI and L3 were not statistically significant. (P=0.713 and 0.070); The differences between before and after their own at L2, L4 and left femoral neck were statistically significant (P=0.031,0.004 and 0.026). BMD increased of 2.15%,4.79% and 2.19%, respectively, were observed. (2) The difference between after 6 months treatment and after 12 months treatment at L1 was statistically significant (P=0.039), increasing of 5.24%. However, the differences at L2-4 and left femoral neck were not statistically significant. (3) The differences between before and after treatment at all positions were statistically significant. BMD increased of 6.02%,4.44%,5.25%,6.30% and 2.19% were observed respectively at L1, L2, L3, L4 and left femoral neck (P values were 0.001, 0.013,0.001,0.001 and 0.027, respectively).ConclusionsPTH(1-34) has positive effects on PMOP.