Rlaxin Levels In Pregnancy With Pre-eclampsia

Objective: To study the role of relaxin in the pathogenesis of pre-eclampsia by measuring serum relaxin levels of the patients with preeclampsia and normal pregnant women in the third trimester.Methods: 15 cases with light preeclampsia patients,25 cases with severe preeclampsia patients and 20 cases of women with normotensive late pregnancy (NLP)were observed. ELISA was used to measure the levels of relaxin in serum of three groups.Results:(1) In serum , the average levels of relaxin in normal pregnancy group, mild preeclampsia group and severe preeclampsia group expression was: (85.46±7.63) pg / ml, (19.91±7.15) pg / ml, (15.93±7.90 ) pg / ml. The difference of serum relaxin levels is significant of three groups (P <0.01). The difference of serum relaxin levels is significant between the group with mild preeclampsia and the normal pregnancy (P <0.01). The difference of serum relaxin levels is significant between the group with severe preeclampsia and the normal pregnancy (P <0.01). The levels of serum relaxin in the group with severe preeclampsia were lower than it in the group with light preeclampsia , but the difference of serum relaxin levels is not statistically significant between the group with light preeclampsia and the group with severe preeclampsia (P> 0.05).(2) The average serum levels of relaxin in severe preeclampsia group was (15.93±7.90) pg / ml, the average systolic blood pressure in them was (164.04±10.47) mmHg, and the mean diastolic blood pressure was (109.36±6.96) mmHg . There is a significant negative correlation between the levels of serum relaxin and the average systolic blood pressure in severe preeclampsia group (P <0.01). There is a significant negative correlation between the levels of serum relaxin and the mean diastolic blood pressure in severe preeclampsia group (P <0.01). Serum relaxin levels in severe preeclampsia patients with elevated levels of systolic and diastolic blood pressure showed a linear downward trend.The average serum levels of relaxin in mild preeclampsia group was (19.91±7.15) pg / ml, the average systolic blood pressure in them was (147.67±5.08) mmHg, and the mean diastolic blood pressure was (98.80±7.47 )mmHg . There is not a gnificant negative correlation between the levels of serum relaxin and the average systolic blood pressure in mild preeclampsia group (P>0.05). There is not a significant negative correlation between the levels of serum relaxin and the mean diastolic blood pressure in mild preeclampsia group (P>0.05). Conclusion :1. The difference of serum relaxin levels is significant between the group with preeclampsia and the normal pregnancy.2. There is a significant negative correlation between the levels of serum relaxin and the average systolic blood and diastolic pressure in severe preeclampsia group.