Preparation And Biological Evaluation Of Polyvinyl Alcohol Hydrogel

Wound dressings on the wound is covered in the process of continuous rehabilitation wound has temporarily replace damaged skin protect the function of the organization, as a barrier to avoid wound be outside environment pollution, and provides excellent healing rehabilitation environment. Ideal dressings should have a few big advantage for, make the wound surfaces in demand keeps the temperature of the range; Control the amount of exudates in certain scope; Stop bacteria, have good antibacterial sex, and promote cell growth; When the changeover of wounds in won't cause secondary injury; Toxicity, stimulating is zero; Water vapor transmittance and gas through rate in relatively optimal value range; Mechanical properties, but no higher a wound dressing can be completely have more advantages. In the present trial, proof hydrogel and water colloid dressings for good wound dressings, so to gel for drug development new dressing matrix to join with practical significance.In this study, previous studies have consolidated the results of the research group, using the dimethyl sulfoxide dissolved in the PVA aqueous solution, frozen using repeated cross-linked PVA hydrogel preparation methods. The chemical properties of PVA hydrogels is not lively, not toxic, biocompatible, aging resistance and so on. Prepared by repeated freezing of polyvinyl alcohol hydrogel with good mechanical strength and flexibility, such hydrogel swelling can not be dissolved in the water, and with the growing number of repeated freezing on the physical and mechanical properties will be improved and this means there is no cross-linked heat and add the other chemical reagents on the stability of dimethyl sulfone has a great guarantee. Dimethyl sulfoxide collagen synthesis in the body the necessary material, dimethyl sulfone can promote wound healing, but also necessary for metabolism and nerve health vitamin B, vitamin C, biotin synthesis and activation work.The advantages of the above material was prepared MSM/PVA hydrogel microstructure by electron microscopy, the hydrogel has a lot of pore structure; mechanical device to test results showed that 12% of the hydrogel with good mechanical stretch Therefore, this study 12% of the PVA hydrogel as a matrix to its inclusion of MSM, statistical analysis of test results of each group do not have differences, indicating that the addition of MSM gel did not change the tension of the water; dehydration of the test The results are not quite different, probably because concentration of the experimental group hydrogel little difference in close proximity in itself, before joining the MSM, the test results and there is no difference, indicating that the addition of MSM did not cause changes on the dehydration rate; water swelling and water absorption is inversely proportional to the concentration of the gel, because the higher the concentration of the gel structure more compact, so the concentration of water-swelling rate is inversely proportional to the swelling ratio of hydrogel hydrogel absorbed the decision the ability to maintain moist wound exudate; water vapor transmission rate in 24h, the water loss in 2.0-2.7g/cm2 can ensure enough water during evaporation of the wound surface, but does not cause excessive water loss,12% and 14% water vapor transmission range in the optimum region. MSM is added after the data analysis of data in each group showed no significant (P> 0.05), that joined the MSM has no effect after water vapor transmission rate, is still within the optimum range of values; release, MSM's release with the time increased and increased, and the release of the 24h, increased to 55%, then the time, through statistical analysis, no difference, indicating that MSM/PVA hydrogel in the MSM completely in 24h, the basic release. The above test results show that the hydrogel prepared this study with excellent performance, which are for the treatment of wounds and promote wound healing have provided favorable conditions.