Effects Of Hemocoagulase On Perioperative Blood Loss And Coagulation In Patients With Low Molecular Heparin Undergoing Total Hip Replacement

Subject: Effects of hemocoagulase on perioperative blood loss and coagulation in patients with low molecular heparin undergoing total hip replacement.Objective: To investigate the effects of hemocoagulase in reducing perioperative blood loss in patients with low molecular heparin undergoing total hip replacement and study its effects on perioperative blood coagulation function so as to provide objective basis for better clinical usage of hemocoagulase. Methods: Fourty ASA I-III patients undergoing total hip replacement under general anesthesia were randomly and double blinded experiment. We excluded the patients suffering from deep vein thrombosis through CDFI. The fourty patients received LMWH for 4000 IU im 12 hours preoperatively. And then the fourty patients randomly received hemocoagulase for 2U iv or mannitol for 50 mg iv 10 minutes preoperatively. The perioperative and postoperative 24 hours bleeding volume was measured respectively; meanwhile, measuring the indices of blood coagulation function preoperative, immediately, 24 hours after operation respectively. We measured the deep vein thrombosis through CDFI 5 days after operation. After the experiment finished, we set Group I that received for hemocoagulase 2U iv 10 mins preoperatively; Group II that received mannitol for 50 mg iv 10 minutes preoperatively. Results:(1)The perioperative and postoperative 24 hours bleeding volume in Group I was less than that in Group II ( P < 0. 01 during operation and P < 0. 05 after operation ); (2) In Group I, RBC, Hb, HCT and PLT immediately and 24 hours after operation were not significantly lower than preoperation ( P>0. 05). (3) In Group II, RBC and Hb immediately after operation were lower than preoperation ( P < 0. 05); and HCT immediately after operation was lower than preoperation ( P < 0. 01); and RBC and Hb 24 hours after operation was lower than preoperation( P < 0. 05); and HCT was lower than preoperation( P < 0. 01).(4)In both groups, APTT, PT, Fbg immediately and 24 hours after operation were not significantly shorter than preoperation (P>0. 05). (5)There are 2 patients in Group I and 1 patients in Groups II suffering from DVT. Conclusion: Preoperative use of hemocoagulase(2U) reduces bleeding volume and hemocoagulase is better in safety.